Facile Synthesis of Boronic-Acid-Functionalized Metal-Organic Framework UiO-66-NH₂@B(OH)₂ with High Selectivity and Sensitivity to Hydrogen Peroxide

As a crucial kind of reactive oxygen species (ROS) and an indispensable signaling molecule, hydrogen peroxide (H₂O₂) plays an irreplaceable role in many pathophysiological events in the organisms. Hence, it is necessary to develop a novel probe for effective monitoring H₂O₂ distribution and concentration in living systems. Herein, a metal-organic framework UiO-66-NH₂@B(OH)₂ is prepared by one-step synthesis method and acted as a novel fluorescence probe for H₂O₂ recognition and detection. The fluorescence signals are greatly enhanced when the UiO-66-NH₂@B(OH)₂ is exposed to H₂O₂, showing high selectivity and sensitivity to H₂O₂ with a detection limitation of 0.056 μM (with signal/noise ratio of 3 : 1). Moreover, the UiO-66-NH₂@B(OH)₂ probe displays superior detection performance against H₂O₂ with a linear range of 0.5∼5 μM in HEPES buffer solution. Attributing to the excellent biocompatibility, the UiO-66-NH₂@B(OH)₂ probe is promising to recognize, detect and monitor H₂O₂ in vivo.