Fabrication of mesoporous silica nanoparticles hybridised with fluorescent AIE-active quinoline-malononitrile for drug delivery and bioimaging

Si Yao; Andong Shao; Wenru Zhao; Shaojia Zhu; Ping Shi; Zhiqian Guo; Weihong Zhu; Jianlin Shi

doi:10.1039/c4ra10114f

Fabrication of mesoporous silica nanoparticles hybridised with fluorescent AIE-active quinoline-malononitrile for drug delivery and bioimaging

Si Yao, Andong Shao, Wenru Zhao^*, Shaojia Zhu, Ping Shi, Zhiqian Guo, Weihong Zhu, Jianlin Shi

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

A novel type of fluorescent mesoporous silica nanoparticle (FMSN) has been successfully synthesised by hybridising mesoporous silica nanospheres with an aggregation-induced emission luminogen, a quinoline-malononitrile derivative. The FMSNs with uniform morphology show excellent AIE-active luminescence and good biocompatibility. Transmission electron microscopy (TEM) demonstrates that the well-ordered mesoporous structure in FMSNs is beneficial for drug delivery. When loaded with doxorubicin (DOX), DOX@FMSNs demonstrate pH-dependent release character and high cytotoxicity towards MCF-7 cancer cells. These FMSNs are expected to be promising multifunctional candidates as both bioimaging agents and drug carriers in cancer therapy.

Original language	English
Pages (from-to)	58976-58981
Number of pages	6
Journal	RSC Advances
Volume	4
Issue number	103
DOIs	https://doi.org/10.1039/c4ra10114f
State	Published - 2014
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1039/c4ra10114f

Cite this

@article{36bb0d79e5b341e98e351d5ac9a95505,

title = "Fabrication of mesoporous silica nanoparticles hybridised with fluorescent AIE-active quinoline-malononitrile for drug delivery and bioimaging",

abstract = "A novel type of fluorescent mesoporous silica nanoparticle (FMSN) has been successfully synthesised by hybridising mesoporous silica nanospheres with an aggregation-induced emission luminogen, a quinoline-malononitrile derivative. The FMSNs with uniform morphology show excellent AIE-active luminescence and good biocompatibility. Transmission electron microscopy (TEM) demonstrates that the well-ordered mesoporous structure in FMSNs is beneficial for drug delivery. When loaded with doxorubicin (DOX), DOX@FMSNs demonstrate pH-dependent release character and high cytotoxicity towards MCF-7 cancer cells. These FMSNs are expected to be promising multifunctional candidates as both bioimaging agents and drug carriers in cancer therapy.",

author = "Si Yao and Andong Shao and Wenru Zhao and Shaojia Zhu and Ping Shi and Zhiqian Guo and Weihong Zhu and Jianlin Shi",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2014.",

year = "2014",

doi = "10.1039/c4ra10114f",

language = "英语",

volume = "4",

pages = "58976--58981",

journal = "RSC Advances",

issn = "2046-2069",

publisher = "Royal Society of Chemistry",

number = "103",

}

TY - JOUR

T1 - Fabrication of mesoporous silica nanoparticles hybridised with fluorescent AIE-active quinoline-malononitrile for drug delivery and bioimaging

AU - Yao, Si

AU - Shao, Andong

AU - Zhao, Wenru

AU - Zhu, Shaojia

AU - Shi, Ping

AU - Guo, Zhiqian

AU - Zhu, Weihong

AU - Shi, Jianlin

PY - 2014

Y1 - 2014

N2 - A novel type of fluorescent mesoporous silica nanoparticle (FMSN) has been successfully synthesised by hybridising mesoporous silica nanospheres with an aggregation-induced emission luminogen, a quinoline-malononitrile derivative. The FMSNs with uniform morphology show excellent AIE-active luminescence and good biocompatibility. Transmission electron microscopy (TEM) demonstrates that the well-ordered mesoporous structure in FMSNs is beneficial for drug delivery. When loaded with doxorubicin (DOX), DOX@FMSNs demonstrate pH-dependent release character and high cytotoxicity towards MCF-7 cancer cells. These FMSNs are expected to be promising multifunctional candidates as both bioimaging agents and drug carriers in cancer therapy.

AB - A novel type of fluorescent mesoporous silica nanoparticle (FMSN) has been successfully synthesised by hybridising mesoporous silica nanospheres with an aggregation-induced emission luminogen, a quinoline-malononitrile derivative. The FMSNs with uniform morphology show excellent AIE-active luminescence and good biocompatibility. Transmission electron microscopy (TEM) demonstrates that the well-ordered mesoporous structure in FMSNs is beneficial for drug delivery. When loaded with doxorubicin (DOX), DOX@FMSNs demonstrate pH-dependent release character and high cytotoxicity towards MCF-7 cancer cells. These FMSNs are expected to be promising multifunctional candidates as both bioimaging agents and drug carriers in cancer therapy.

UR - https://www.scopus.com/pages/publications/84911914564

U2 - 10.1039/c4ra10114f

DO - 10.1039/c4ra10114f

M3 - 文章

AN - SCOPUS:84911914564

SN - 2046-2069

VL - 4

SP - 58976

EP - 58981

JO - RSC Advances

JF - RSC Advances

IS - 103

ER -

Fabrication of mesoporous silica nanoparticles hybridised with fluorescent AIE-active quinoline-malononitrile for drug delivery and bioimaging

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this