Expression of a novel Krüpple-like zinc-finger gene, ZNF382, in human heart

Kaimei Luo; Wuzhou Yuan; Chuanbing Zhu; Yongqing Li; Yuequn Wang; Weiqi Zeng; Wei Jiao; Mingyao Liu; Xiushan Wu

doi:10.1016/S0006-291X(02)02700-6

Expression of a novel Krüpple-like zinc-finger gene, ZNF382, in human heart

Kaimei Luo
, Wuzhou Yuan
, Chuanbing Zhu
, Yongqing Li
, Yuequn Wang
, Weiqi Zeng
, Wei Jiao
, Mingyao Liu
, Xiushan Wu^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

With the aim of identifying genes involved in human heart development and disease, we have isolated a novel KRAB-related zinc-finger gene named ZNF382 from heart cDNA library. The ZNF382 gene has a predicted 548-amino acid open reading frame, encoding a putative 64 kDa zinc-finger protein. The N-terminus of the ZNF382 coding region has a well-conserved Krüpple-associated box domain that consists of KRAB boxes A and B, whereas the C-terminus contains a Krüpple-type zinc-finger domain possessing nine C₂H₂ zinc-finger motifs in tandem arrays. The ZNF382 gene is mapped to chromosome 19q13.13. Northern blot analysis indicates that a 2.9-kb transcript specific for ZNF382 is expressed at very early embryonic stage of human (at least earlier than gestation 34 day) and widely in human embryo tissues. At the adult stage, ZNF382 expression is restricted largely to heart tissue suggesting a potential role in heart development and function.

Original language	English
Pages (from-to)	606-612
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	299
Issue number	4
DOIs	https://doi.org/10.1016/S0006-291X(02)02700-6
State	Published - 2002
Externally published	Yes

Keywords

CH zinc finger
Heart development
KRAB box
Transcription factor
ZNF382

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0006-291X(02)02700-6

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title = "Expression of a novel Kr{\"u}pple-like zinc-finger gene, ZNF382, in human heart",

abstract = "With the aim of identifying genes involved in human heart development and disease, we have isolated a novel KRAB-related zinc-finger gene named ZNF382 from heart cDNA library. The ZNF382 gene has a predicted 548-amino acid open reading frame, encoding a putative 64 kDa zinc-finger protein. The N-terminus of the ZNF382 coding region has a well-conserved Kr{\"u}pple-associated box domain that consists of KRAB boxes A and B, whereas the C-terminus contains a Kr{\"u}pple-type zinc-finger domain possessing nine C2H2 zinc-finger motifs in tandem arrays. The ZNF382 gene is mapped to chromosome 19q13.13. Northern blot analysis indicates that a 2.9-kb transcript specific for ZNF382 is expressed at very early embryonic stage of human (at least earlier than gestation 34 day) and widely in human embryo tissues. At the adult stage, ZNF382 expression is restricted largely to heart tissue suggesting a potential role in heart development and function.",

keywords = "CH zinc finger, Heart development, KRAB box, Transcription factor, ZNF382",

author = "Kaimei Luo and Wuzhou Yuan and Chuanbing Zhu and Yongqing Li and Yuequn Wang and Weiqi Zeng and Wei Jiao and Mingyao Liu and Xiushan Wu",

year = "2002",

doi = "10.1016/S0006-291X(02)02700-6",

language = "英语",

volume = "299",

pages = "606--612",

journal = "Biochemical and Biophysical Research Communications",

issn = "0006-291X",

publisher = "Elsevier B.V.",

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TY - JOUR

T1 - Expression of a novel Krüpple-like zinc-finger gene, ZNF382, in human heart

AU - Luo, Kaimei

AU - Yuan, Wuzhou

AU - Zhu, Chuanbing

AU - Li, Yongqing

AU - Wang, Yuequn

AU - Zeng, Weiqi

AU - Jiao, Wei

AU - Liu, Mingyao

AU - Wu, Xiushan

PY - 2002

Y1 - 2002

N2 - With the aim of identifying genes involved in human heart development and disease, we have isolated a novel KRAB-related zinc-finger gene named ZNF382 from heart cDNA library. The ZNF382 gene has a predicted 548-amino acid open reading frame, encoding a putative 64 kDa zinc-finger protein. The N-terminus of the ZNF382 coding region has a well-conserved Krüpple-associated box domain that consists of KRAB boxes A and B, whereas the C-terminus contains a Krüpple-type zinc-finger domain possessing nine C2H2 zinc-finger motifs in tandem arrays. The ZNF382 gene is mapped to chromosome 19q13.13. Northern blot analysis indicates that a 2.9-kb transcript specific for ZNF382 is expressed at very early embryonic stage of human (at least earlier than gestation 34 day) and widely in human embryo tissues. At the adult stage, ZNF382 expression is restricted largely to heart tissue suggesting a potential role in heart development and function.

AB - With the aim of identifying genes involved in human heart development and disease, we have isolated a novel KRAB-related zinc-finger gene named ZNF382 from heart cDNA library. The ZNF382 gene has a predicted 548-amino acid open reading frame, encoding a putative 64 kDa zinc-finger protein. The N-terminus of the ZNF382 coding region has a well-conserved Krüpple-associated box domain that consists of KRAB boxes A and B, whereas the C-terminus contains a Krüpple-type zinc-finger domain possessing nine C2H2 zinc-finger motifs in tandem arrays. The ZNF382 gene is mapped to chromosome 19q13.13. Northern blot analysis indicates that a 2.9-kb transcript specific for ZNF382 is expressed at very early embryonic stage of human (at least earlier than gestation 34 day) and widely in human embryo tissues. At the adult stage, ZNF382 expression is restricted largely to heart tissue suggesting a potential role in heart development and function.

KW - CH zinc finger

KW - Heart development

KW - KRAB box

KW - Transcription factor

KW - ZNF382

UR - https://www.scopus.com/pages/publications/0036921617

U2 - 10.1016/S0006-291X(02)02700-6

DO - 10.1016/S0006-291X(02)02700-6

M3 - 文章

C2 - 12459182

AN - SCOPUS:0036921617

SN - 0006-291X

VL - 299

SP - 606

EP - 612

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 4

ER -

Expression of a novel Krüpple-like zinc-finger gene, ZNF382, in human heart

Abstract

Keywords

UN SDGs

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