Exploring the pathways and targets of Shexiang Baoxin pill for coronary heart disease through a network pharmacology approach

Shou De Zhang; Zhan Hai Su; Rui Hui Liu; Yan Yan Diao; Shi Liang Li; Ya-Ping-Hua; Hong Lin Li; Wei Dong Zhang; Wei Dong Zhang

doi:10.4103/wjtcm.wjtcm_18_18

Exploring the pathways and targets of Shexiang Baoxin pill for coronary heart disease through a network pharmacology approach

Shou De Zhang
, Zhan Hai Su
, Rui Hui Liu
, Yan Yan Diao
, Shi Liang Li
, Ya-Ping-Hua
, Hong Lin Li
, Wei Dong Zhang
, Wei Dong Zhang

Qinghai University
East China University of Science and Technology
Naval Medical University
University of Bergen

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

To investigate the network pharmacology of Shexiang Baoxin pill (SBP) and systematically analyze the mechanisms of SBP. Methods: In this study, we excavated all the targets of 26 constituents of SBP which were identified in rat plasma though literature mining and target calculation (reverse docking and similarity search) and analyzed the multiple pharmacology actions of SBP comprehensively through a network pharmacology approach. Results: In the end, a total of 330 Homo sapiens targets were identified for 26 blood constituents of SBP. Moreover, the pathway enrichment analysis found that these targets mapped into 171 KEGG pathways and 31 of which were more enriched. Among these identified pathways, 3 pathways were selected for analyzing the mechanisms of SBP for treating coronary heart disease. Conclusion: This study systematically illustrated the mechanisms of the SBP by analyzing the corresponding 'drug-target-pathway-disease' interaction network.

Original language	English
Pages (from-to)	137-146
Number of pages	10
Journal	World Journal of Traditional Chinese Medicine
Volume	4
Issue number	4
DOIs	https://doi.org/10.4103/wjtcm.wjtcm_18_18
State	Published - 1 Oct 2018
Externally published	Yes

Keywords

Coronary heart disease
Shexiang Baoxin pill
network pharmacology
reverse docking
similarity search

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10.4103/wjtcm.wjtcm_18_18

Cite this

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title = "Exploring the pathways and targets of Shexiang Baoxin pill for coronary heart disease through a network pharmacology approach",

abstract = "To investigate the network pharmacology of Shexiang Baoxin pill (SBP) and systematically analyze the mechanisms of SBP. Methods: In this study, we excavated all the targets of 26 constituents of SBP which were identified in rat plasma though literature mining and target calculation (reverse docking and similarity search) and analyzed the multiple pharmacology actions of SBP comprehensively through a network pharmacology approach. Results: In the end, a total of 330 Homo sapiens targets were identified for 26 blood constituents of SBP. Moreover, the pathway enrichment analysis found that these targets mapped into 171 KEGG pathways and 31 of which were more enriched. Among these identified pathways, 3 pathways were selected for analyzing the mechanisms of SBP for treating coronary heart disease. Conclusion: This study systematically illustrated the mechanisms of the SBP by analyzing the corresponding 'drug-target-pathway-disease' interaction network.",

keywords = "Coronary heart disease, Shexiang Baoxin pill, network pharmacology, reverse docking, similarity search",

author = "Zhang, \{Shou De\} and Su, \{Zhan Hai\} and Liu, \{Rui Hui\} and Diao, \{Yan Yan\} and Li, \{Shi Liang\} and Ya-Ping-Hua and Li, \{Hong Lin\} and Zhang, \{Wei Dong\} and Zhang, \{Wei Dong\}",

note = "Publisher Copyright: {\textcopyright} 2018 World Journal of Traditional Chinese Medicine Published by Wolters Kluwer - Medknow.",

year = "2018",

month = oct,

day = "1",

doi = "10.4103/wjtcm.wjtcm\_18\_18",

language = "英语",

volume = "4",

pages = "137--146",

journal = "World Journal of Traditional Chinese Medicine",

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TY - JOUR

T1 - Exploring the pathways and targets of Shexiang Baoxin pill for coronary heart disease through a network pharmacology approach

AU - Zhang, Shou De

AU - Su, Zhan Hai

AU - Liu, Rui Hui

AU - Diao, Yan Yan

AU - Li, Shi Liang

AU - Ya-Ping-Hua,

AU - Li, Hong Lin

AU - Zhang, Wei Dong

PY - 2018/10/1

Y1 - 2018/10/1

N2 - To investigate the network pharmacology of Shexiang Baoxin pill (SBP) and systematically analyze the mechanisms of SBP. Methods: In this study, we excavated all the targets of 26 constituents of SBP which were identified in rat plasma though literature mining and target calculation (reverse docking and similarity search) and analyzed the multiple pharmacology actions of SBP comprehensively through a network pharmacology approach. Results: In the end, a total of 330 Homo sapiens targets were identified for 26 blood constituents of SBP. Moreover, the pathway enrichment analysis found that these targets mapped into 171 KEGG pathways and 31 of which were more enriched. Among these identified pathways, 3 pathways were selected for analyzing the mechanisms of SBP for treating coronary heart disease. Conclusion: This study systematically illustrated the mechanisms of the SBP by analyzing the corresponding 'drug-target-pathway-disease' interaction network.

AB - To investigate the network pharmacology of Shexiang Baoxin pill (SBP) and systematically analyze the mechanisms of SBP. Methods: In this study, we excavated all the targets of 26 constituents of SBP which were identified in rat plasma though literature mining and target calculation (reverse docking and similarity search) and analyzed the multiple pharmacology actions of SBP comprehensively through a network pharmacology approach. Results: In the end, a total of 330 Homo sapiens targets were identified for 26 blood constituents of SBP. Moreover, the pathway enrichment analysis found that these targets mapped into 171 KEGG pathways and 31 of which were more enriched. Among these identified pathways, 3 pathways were selected for analyzing the mechanisms of SBP for treating coronary heart disease. Conclusion: This study systematically illustrated the mechanisms of the SBP by analyzing the corresponding 'drug-target-pathway-disease' interaction network.

KW - Coronary heart disease

KW - Shexiang Baoxin pill

KW - network pharmacology

KW - reverse docking

KW - similarity search

UR - https://www.scopus.com/pages/publications/85086130579

U2 - 10.4103/wjtcm.wjtcm_18_18

DO - 10.4103/wjtcm.wjtcm_18_18

M3 - 文章

AN - SCOPUS:85086130579

SN - 2311-8571

VL - 4

SP - 137

EP - 146

JO - World Journal of Traditional Chinese Medicine

JF - World Journal of Traditional Chinese Medicine

IS - 4

ER -

Exploring the pathways and targets of Shexiang Baoxin pill for coronary heart disease through a network pharmacology approach

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Keywords

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