Abstract
Nitrone induced 1,3-dipolar [3 + 2] cycloadditions were studied to construct the core structure of Calyciphylline A-type Daphniphyllum alkaloids. This approach is capable of installing the cis-hydroindole A-C ring as well as the spiro-A-C-E ring with the all-carbon quaternary centers at C-5 and C-8, and has been successfully used in the total synthesis of himalensine A. It also lays the foundation for the synthesis of challenging Calyciphylline A-type alkaloids, such as daphniyunnine A.
| Original language | English |
|---|---|
| Pages (from-to) | 3781-3785 |
| Number of pages | 5 |
| Journal | Organic Chemistry Frontiers |
| Volume | 6 |
| Issue number | 22 |
| DOIs | |
| State | Published - 21 Nov 2019 |