TY - GEN
T1 - Evaluation of erythropoietin efficacy on diabetic rats based on microscopic hyperspectral imaging technique
AU - Dai, Chunni
AU - Li, Qingli
AU - Liu, Jingao
AU - Wang, Yiting
PY - 2010
Y1 - 2010
N2 - Microscopic hyperspectral imaging technology instead of traditional method is employed to evaluate the therapeutic effects of Erythropoietin (EPO) on diabetic rats. As a relatively new method for biomedical discipline, hyperspectral imaging coupled with microscope can supply not only a variety of dissimilar wavelengths images but also optical spectra at every pixel in these images. With the data cube taken by microscopic pushbroom hyperspectral imager, the spectra of the normal, diabetic, and EPO-treated rats were compared to carry out quantitative analysis. Results show the spectral signature of the EPO group was more similar to that of the Normal than that of the Diabetes to the Normal. The results suggest EPO may prevent cell apoptosis and has protective effect on rat DR at a certain level. Owing to its effective application to the validation of drug efficacy, microscopic hyperspectral imager may probably provide a potential approach for medical researchers in future.
AB - Microscopic hyperspectral imaging technology instead of traditional method is employed to evaluate the therapeutic effects of Erythropoietin (EPO) on diabetic rats. As a relatively new method for biomedical discipline, hyperspectral imaging coupled with microscope can supply not only a variety of dissimilar wavelengths images but also optical spectra at every pixel in these images. With the data cube taken by microscopic pushbroom hyperspectral imager, the spectra of the normal, diabetic, and EPO-treated rats were compared to carry out quantitative analysis. Results show the spectral signature of the EPO group was more similar to that of the Normal than that of the Diabetes to the Normal. The results suggest EPO may prevent cell apoptosis and has protective effect on rat DR at a certain level. Owing to its effective application to the validation of drug efficacy, microscopic hyperspectral imager may probably provide a potential approach for medical researchers in future.
KW - Diabetic retinopathy
KW - Erythropoietin
KW - Hyperspectral imaging
UR - https://www.scopus.com/pages/publications/77956148556
U2 - 10.1109/ICBBE.2010.5515843
DO - 10.1109/ICBBE.2010.5515843
M3 - 会议稿件
AN - SCOPUS:77956148556
SN - 9781424447138
T3 - 2010 4th International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2010
BT - 2010 4th International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2010
T2 - 4th International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2010
Y2 - 18 June 2010 through 20 June 2010
ER -
