Evaluation of enzyme inhibition kinetics in drug-drug interactions

Ang Chen; Xuan Qin; Yu Tang; Mingyao Liu; Xin Wang

doi:10.1016/j.cbi.2014.10.010

Evaluation of enzyme inhibition kinetics in drug-drug interactions

Ang Chen
, Xuan Qin
, Yu Tang
, Mingyao Liu
, Xin Wang^*

^*Corresponding author for this work

School of Life Sciences

East China Normal University
Texas A&M University

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Inhibition of CYP enzymes is thought to be the most common cause of drug-drug and/or herb-drug interactions. To characterize the inhibition of CYP enzymes activities by chemicals, enzyme inhibition kinetic experiments are usually carried out. The purpose of this letter is to call attention to evaluate the enzyme inhibition kinetics in drug-drug interactions.

Original language	English
Pages (from-to)	133-134
Number of pages	2
Journal	Chemico-Biological Interactions
Volume	222
DOIs	https://doi.org/10.1016/j.cbi.2014.10.010
State	Published - 5 Oct 2014

Keywords

CYP enzymes
Drug-drug interactions
Enzyme inhibition kinetics

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10.1016/j.cbi.2014.10.010

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@article{897774995e834e17b9593cc31524c6bf,

title = "Evaluation of enzyme inhibition kinetics in drug-drug interactions",

abstract = "Inhibition of CYP enzymes is thought to be the most common cause of drug-drug and/or herb-drug interactions. To characterize the inhibition of CYP enzymes activities by chemicals, enzyme inhibition kinetic experiments are usually carried out. The purpose of this letter is to call attention to evaluate the enzyme inhibition kinetics in drug-drug interactions.",

keywords = "CYP enzymes, Drug-drug interactions, Enzyme inhibition kinetics",

author = "Ang Chen and Xuan Qin and Yu Tang and Mingyao Liu and Xin Wang",

year = "2014",

month = oct,

day = "5",

doi = "10.1016/j.cbi.2014.10.010",

language = "英语",

volume = "222",

pages = "133--134",

journal = "Chemico-Biological Interactions",

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publisher = "Elsevier Ireland Ltd",

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TY - JOUR

T1 - Evaluation of enzyme inhibition kinetics in drug-drug interactions

AU - Chen, Ang

AU - Qin, Xuan

AU - Tang, Yu

AU - Liu, Mingyao

AU - Wang, Xin

PY - 2014/10/5

Y1 - 2014/10/5

N2 - Inhibition of CYP enzymes is thought to be the most common cause of drug-drug and/or herb-drug interactions. To characterize the inhibition of CYP enzymes activities by chemicals, enzyme inhibition kinetic experiments are usually carried out. The purpose of this letter is to call attention to evaluate the enzyme inhibition kinetics in drug-drug interactions.

AB - Inhibition of CYP enzymes is thought to be the most common cause of drug-drug and/or herb-drug interactions. To characterize the inhibition of CYP enzymes activities by chemicals, enzyme inhibition kinetic experiments are usually carried out. The purpose of this letter is to call attention to evaluate the enzyme inhibition kinetics in drug-drug interactions.

KW - CYP enzymes

KW - Drug-drug interactions

KW - Enzyme inhibition kinetics

UR - https://www.scopus.com/pages/publications/84908615051

U2 - 10.1016/j.cbi.2014.10.010

DO - 10.1016/j.cbi.2014.10.010

M3 - 文章

C2 - 25451570

AN - SCOPUS:84908615051

SN - 0009-2797

VL - 222

SP - 133

EP - 134

JO - Chemico-Biological Interactions

JF - Chemico-Biological Interactions

ER -

Evaluation of enzyme inhibition kinetics in drug-drug interactions

Abstract

Keywords

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