TY - GEN
T1 - EUK1111 attenuates scopolamine-induced learning deficits in the passive avoidance test
AU - Zeng, Qingwen
AU - Duan, Yale
AU - Cao, Xiaohua
AU - Tao, Bairui
PY - 2012
Y1 - 2012
N2 - The aim of the experiment was to investigate the effects of the EUK1111 on passive avoidance of amnestic mice model induced by scopolamine. Five groups were divided: Control, model, model + high concentration (260 mg/kg), model + middle concentration (104.2 mg/kg) and model + low concentration (5.2 mg/kg). An open field experiment was conducted to test the locomotor activity after EUK1111 was taken orally 30 days. Scopolamine was injected intraperitoneal (1.5 mg/kg ) 10 minutes before passive avoidance test was conducted. There were no significant difference among the groups on move time, total moves, move velocity and move distance (P > 0. 05). However, in passive avoidance test, the latencies to dark side were significantly longer in model + high concentration group, model + middle concentration group than model group ( P lt; 0. 05). It indicates that EUK1111 may attenuate scopolamine induced learning deficits.
AB - The aim of the experiment was to investigate the effects of the EUK1111 on passive avoidance of amnestic mice model induced by scopolamine. Five groups were divided: Control, model, model + high concentration (260 mg/kg), model + middle concentration (104.2 mg/kg) and model + low concentration (5.2 mg/kg). An open field experiment was conducted to test the locomotor activity after EUK1111 was taken orally 30 days. Scopolamine was injected intraperitoneal (1.5 mg/kg ) 10 minutes before passive avoidance test was conducted. There were no significant difference among the groups on move time, total moves, move velocity and move distance (P > 0. 05). However, in passive avoidance test, the latencies to dark side were significantly longer in model + high concentration group, model + middle concentration group than model group ( P lt; 0. 05). It indicates that EUK1111 may attenuate scopolamine induced learning deficits.
KW - EUK1111
KW - Passive avoidance
KW - Scopolamine
UR - https://www.scopus.com/pages/publications/80053616800
U2 - 10.4028/www.scientific.net/AMR.345.276
DO - 10.4028/www.scientific.net/AMR.345.276
M3 - 会议稿件
AN - SCOPUS:80053616800
SN - 9783037852576
T3 - Advanced Materials Research
SP - 276
EP - 279
BT - Smart Materials and Nanotechnology in Engineering, SMNE2011
T2 - 2011 International Conference on Smart Materials and Nanotechnology in Engineering, SMNE 2011
Y2 - 17 September 2011 through 18 September 2011
ER -