Enzyme-free amplified SERS immunoassay for the ultrasensitive detection of disease biomarkers

Xuan Xuan Zhang; Duo Xu; Dan Guo; Huan Xing Han; Da Wei Li; Wei Ma

doi:10.1039/c9cc09379f

Enzyme-free amplified SERS immunoassay for the ultrasensitive detection of disease biomarkers

Xuan Xuan Zhang, Duo Xu, Dan Guo, Huan Xing Han, Da Wei Li, Wei Ma

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

We developed a novel enzyme-free amplified SERS immunoassay by combining silver nanoparticle (AgNP)-linked immunoreaction and SERS transduction for the detection of disease biomarkers. As a proof of concept, our method was successfully illustrated with the disease biomarker α-fetoprotein with the detection limit of 3.3 × 10^-13 g mL^-1 and a double-blind experiment consisting of tens of serum samples was performed to confirm its reliability.

Original language	English
Pages (from-to)	2933-2936
Number of pages	4
Journal	Chemical Communications
Volume	56
Issue number	19
DOIs	https://doi.org/10.1039/c9cc09379f
State	Published - 7 Mar 2020
Externally published	Yes

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title = "Enzyme-free amplified SERS immunoassay for the ultrasensitive detection of disease biomarkers",

abstract = "We developed a novel enzyme-free amplified SERS immunoassay by combining silver nanoparticle (AgNP)-linked immunoreaction and SERS transduction for the detection of disease biomarkers. As a proof of concept, our method was successfully illustrated with the disease biomarker α-fetoprotein with the detection limit of 3.3 × 10-13 g mL-1 and a double-blind experiment consisting of tens of serum samples was performed to confirm its reliability.",

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AU - Zhang, Xuan Xuan

AU - Xu, Duo

AU - Guo, Dan

AU - Han, Huan Xing

AU - Li, Da Wei

AU - Ma, Wei

N1 - Publisher Copyright: This journal is © The Royal Society of Chemistry.

PY - 2020/3/7

Y1 - 2020/3/7

N2 - We developed a novel enzyme-free amplified SERS immunoassay by combining silver nanoparticle (AgNP)-linked immunoreaction and SERS transduction for the detection of disease biomarkers. As a proof of concept, our method was successfully illustrated with the disease biomarker α-fetoprotein with the detection limit of 3.3 × 10-13 g mL-1 and a double-blind experiment consisting of tens of serum samples was performed to confirm its reliability.

AB - We developed a novel enzyme-free amplified SERS immunoassay by combining silver nanoparticle (AgNP)-linked immunoreaction and SERS transduction for the detection of disease biomarkers. As a proof of concept, our method was successfully illustrated with the disease biomarker α-fetoprotein with the detection limit of 3.3 × 10-13 g mL-1 and a double-blind experiment consisting of tens of serum samples was performed to confirm its reliability.

UR - https://www.scopus.com/pages/publications/85081079779

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DO - 10.1039/c9cc09379f

M3 - 文章

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JO - Chemical Communications

JF - Chemical Communications

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ER -

Enzyme-free amplified SERS immunoassay for the ultrasensitive detection of disease biomarkers

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