Engineering naphthalimide-cyanine integrated near-infrared dye into ROS-responsive nanohybrids for tumor PDT/PTT/chemotherapy

Tongxia Jin; Di Cheng; Guanyu Jiang; Wenqian Xing; Peiwen Liu; Bin Wang; Weiping Zhu; Haitao Sun; Zhenrong Sun; Yufang Xu; Xuhong Qian

doi:10.1016/j.bioactmat.2021.12.009

Engineering naphthalimide-cyanine integrated near-infrared dye into ROS-responsive nanohybrids for tumor PDT/PTT/chemotherapy

Tongxia Jin
, Di Cheng
, Guanyu Jiang
, Wenqian Xing
, Peiwen Liu
, Bin Wang
, Weiping Zhu^*
, Haitao Sun^*
, Zhenrong Sun
, Yufang Xu
, Xuhong Qian^*

^*Corresponding author for this work

Institute for Advanced Study in Precision Spectroscopy

Research output: Contribution to journal › Article › peer-review

109 Scopus citations

Abstract

Photodynamic (PDT) and photothermal therapies (PTT) are emerging treatments for tumour ablation. Organic dyes such as porphyrin, chlorin, phthalocyanine, boron-dipyrromethene and cyanine are the clinically or preclinically used photosensitizer or photothermal agents. Development of structurally diverse near-infrared dyes with long absorption wavelength is of great significance for PDT and PTT. Herein, we report a novel near-infrared dye ML880 with naphthalimide modified cyanine skeleton. The introduction of naphthalimide moiety results in stronger electron delocalization and larger redshift in emission compared with IR820. Furthermore, ML880 is co-loaded with chemotherapeutic drug into ROS-responsive mesoporous organosilica (RMON) to construct nanomedicine NBD&ML@RMON, which exhibits remarkable tumor inhibition effects through PDT/PTT/chemotherapy in vivo.

Original language	English
Pages (from-to)	42-51
Number of pages	10
Journal	Bioactive Materials
Volume	14
DOIs	https://doi.org/10.1016/j.bioactmat.2021.12.009
State	Published - Aug 2022

Keywords

Combination therapy
Drug delivery system
Integration strategy
Near-infrared dye
Phototherapy

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10.1016/j.bioactmat.2021.12.009

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@article{4671fbb42c3d46bba1639c8d4bd99f38,

title = "Engineering naphthalimide-cyanine integrated near-infrared dye into ROS-responsive nanohybrids for tumor PDT/PTT/chemotherapy",

abstract = "Photodynamic (PDT) and photothermal therapies (PTT) are emerging treatments for tumour ablation. Organic dyes such as porphyrin, chlorin, phthalocyanine, boron-dipyrromethene and cyanine are the clinically or preclinically used photosensitizer or photothermal agents. Development of structurally diverse near-infrared dyes with long absorption wavelength is of great significance for PDT and PTT. Herein, we report a novel near-infrared dye ML880 with naphthalimide modified cyanine skeleton. The introduction of naphthalimide moiety results in stronger electron delocalization and larger redshift in emission compared with IR820. Furthermore, ML880 is co-loaded with chemotherapeutic drug into ROS-responsive mesoporous organosilica (RMON) to construct nanomedicine NBD\&ML@RMON, which exhibits remarkable tumor inhibition effects through PDT/PTT/chemotherapy in vivo.",

keywords = "Combination therapy, Drug delivery system, Integration strategy, Near-infrared dye, Phototherapy",

author = "Tongxia Jin and Di Cheng and Guanyu Jiang and Wenqian Xing and Peiwen Liu and Bin Wang and Weiping Zhu and Haitao Sun and Zhenrong Sun and Yufang Xu and Xuhong Qian",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors",

year = "2022",

month = aug,

doi = "10.1016/j.bioactmat.2021.12.009",

language = "英语",

volume = "14",

pages = "42--51",

journal = "Bioactive Materials",

issn = "2452-199X",

publisher = "KeAi Communications Co.",

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TY - JOUR

T1 - Engineering naphthalimide-cyanine integrated near-infrared dye into ROS-responsive nanohybrids for tumor PDT/PTT/chemotherapy

AU - Jin, Tongxia

AU - Cheng, Di

AU - Jiang, Guanyu

AU - Xing, Wenqian

AU - Liu, Peiwen

AU - Wang, Bin

AU - Zhu, Weiping

AU - Sun, Haitao

AU - Sun, Zhenrong

AU - Xu, Yufang

AU - Qian, Xuhong

PY - 2022/8

Y1 - 2022/8

N2 - Photodynamic (PDT) and photothermal therapies (PTT) are emerging treatments for tumour ablation. Organic dyes such as porphyrin, chlorin, phthalocyanine, boron-dipyrromethene and cyanine are the clinically or preclinically used photosensitizer or photothermal agents. Development of structurally diverse near-infrared dyes with long absorption wavelength is of great significance for PDT and PTT. Herein, we report a novel near-infrared dye ML880 with naphthalimide modified cyanine skeleton. The introduction of naphthalimide moiety results in stronger electron delocalization and larger redshift in emission compared with IR820. Furthermore, ML880 is co-loaded with chemotherapeutic drug into ROS-responsive mesoporous organosilica (RMON) to construct nanomedicine NBD&ML@RMON, which exhibits remarkable tumor inhibition effects through PDT/PTT/chemotherapy in vivo.

AB - Photodynamic (PDT) and photothermal therapies (PTT) are emerging treatments for tumour ablation. Organic dyes such as porphyrin, chlorin, phthalocyanine, boron-dipyrromethene and cyanine are the clinically or preclinically used photosensitizer or photothermal agents. Development of structurally diverse near-infrared dyes with long absorption wavelength is of great significance for PDT and PTT. Herein, we report a novel near-infrared dye ML880 with naphthalimide modified cyanine skeleton. The introduction of naphthalimide moiety results in stronger electron delocalization and larger redshift in emission compared with IR820. Furthermore, ML880 is co-loaded with chemotherapeutic drug into ROS-responsive mesoporous organosilica (RMON) to construct nanomedicine NBD&ML@RMON, which exhibits remarkable tumor inhibition effects through PDT/PTT/chemotherapy in vivo.

KW - Combination therapy

KW - Drug delivery system

KW - Integration strategy

KW - Near-infrared dye

KW - Phototherapy

UR - https://www.scopus.com/pages/publications/85121650233

U2 - 10.1016/j.bioactmat.2021.12.009

DO - 10.1016/j.bioactmat.2021.12.009

M3 - 文章

AN - SCOPUS:85121650233

SN - 2452-199X

VL - 14

SP - 42

EP - 51

JO - Bioactive Materials

JF - Bioactive Materials

ER -

Engineering naphthalimide-cyanine integrated near-infrared dye into ROS-responsive nanohybrids for tumor PDT/PTT/chemotherapy

Abstract

Keywords

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