Engineering Low-Fouling and pH-Degradable Capsules through the Assembly of Metal-Phenolic Networks

Yi Ju; Jiwei Cui; Markus Müllner; Tomoya Suma; Ming Hu; Frank Caruso

doi:10.1021/bm5017139

Engineering Low-Fouling and pH-Degradable Capsules through the Assembly of Metal-Phenolic Networks

Yi Ju, Jiwei Cui, Markus Müllner, Tomoya Suma, Ming Hu, Frank Caruso

University of Melbourne

Research output: Contribution to journal › Article › peer-review

135 Scopus citations

Abstract

Metal-phenolic coordination chemistry provides a simple and rapid way to fabricate ultrathin films. Here, we report a facile strategy for the preparation of low-fouling and pH-degradable metal-phenolic network (MPN) capsules using a synthetic polyphenol derivative, poly(ethylene glycol) (PEG)-polyphenol, as a building block. PEG-MPN capsules exhibit reduced nonspecific protein adsorption and cell association compared with tannic acid (TA)-MPN capsules. In addition, they show faster disassembly at a biologically relevant pH (5) than TA-MPN capsules (80% in 5 h vs 30% in 10 days). PEG-MPN capsules combine both the low fouling properties of PEG and the advantages of the MPN-driven assembly process (e.g., fast assembly and pH-degradability). (Figure Presented).

Original language	English
Pages (from-to)	807-814
Number of pages	8
Journal	Biomacromolecules
Volume	16
Issue number	3
DOIs	https://doi.org/10.1021/bm5017139
State	Published - 9 Mar 2015
Externally published	Yes

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title = "Engineering Low-Fouling and pH-Degradable Capsules through the Assembly of Metal-Phenolic Networks",

abstract = "Metal-phenolic coordination chemistry provides a simple and rapid way to fabricate ultrathin films. Here, we report a facile strategy for the preparation of low-fouling and pH-degradable metal-phenolic network (MPN) capsules using a synthetic polyphenol derivative, poly(ethylene glycol) (PEG)-polyphenol, as a building block. PEG-MPN capsules exhibit reduced nonspecific protein adsorption and cell association compared with tannic acid (TA)-MPN capsules. In addition, they show faster disassembly at a biologically relevant pH (5) than TA-MPN capsules (80\% in 5 h vs 30\% in 10 days). PEG-MPN capsules combine both the low fouling properties of PEG and the advantages of the MPN-driven assembly process (e.g., fast assembly and pH-degradability). (Figure Presented).",

author = "Yi Ju and Jiwei Cui and Markus M{\"u}llner and Tomoya Suma and Ming Hu and Frank Caruso",

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T1 - Engineering Low-Fouling and pH-Degradable Capsules through the Assembly of Metal-Phenolic Networks

AU - Ju, Yi

AU - Cui, Jiwei

AU - Müllner, Markus

AU - Suma, Tomoya

AU - Hu, Ming

AU - Caruso, Frank

PY - 2015/3/9

Y1 - 2015/3/9

N2 - Metal-phenolic coordination chemistry provides a simple and rapid way to fabricate ultrathin films. Here, we report a facile strategy for the preparation of low-fouling and pH-degradable metal-phenolic network (MPN) capsules using a synthetic polyphenol derivative, poly(ethylene glycol) (PEG)-polyphenol, as a building block. PEG-MPN capsules exhibit reduced nonspecific protein adsorption and cell association compared with tannic acid (TA)-MPN capsules. In addition, they show faster disassembly at a biologically relevant pH (5) than TA-MPN capsules (80% in 5 h vs 30% in 10 days). PEG-MPN capsules combine both the low fouling properties of PEG and the advantages of the MPN-driven assembly process (e.g., fast assembly and pH-degradability). (Figure Presented).

AB - Metal-phenolic coordination chemistry provides a simple and rapid way to fabricate ultrathin films. Here, we report a facile strategy for the preparation of low-fouling and pH-degradable metal-phenolic network (MPN) capsules using a synthetic polyphenol derivative, poly(ethylene glycol) (PEG)-polyphenol, as a building block. PEG-MPN capsules exhibit reduced nonspecific protein adsorption and cell association compared with tannic acid (TA)-MPN capsules. In addition, they show faster disassembly at a biologically relevant pH (5) than TA-MPN capsules (80% in 5 h vs 30% in 10 days). PEG-MPN capsules combine both the low fouling properties of PEG and the advantages of the MPN-driven assembly process (e.g., fast assembly and pH-degradability). (Figure Presented).

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M3 - 文章

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Engineering Low-Fouling and pH-Degradable Capsules through the Assembly of Metal-Phenolic Networks

Abstract

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