Enantioselective oxidative functionalization of the Csp3-H bond adjacent to a nitrogen atom for rapid access to β-hydroxyl-α-amino acid derivatives

Lin Qiu; Xin Guo; Yu Qian; Changcheng Jing; Chaoqun Ma; Shunying Liu; Wenhao Hu

doi:10.1039/c6cc04710f

Enantioselective oxidative functionalization of the C_sp³-H bond adjacent to a nitrogen atom for rapid access to β-hydroxyl-α-amino acid derivatives

Lin Qiu
, Xin Guo
, Yu Qian
, Changcheng Jing
, Chaoqun Ma
, Shunying Liu^*
, Wenhao Hu

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Highly chemoselective and enantioselective one-pot reactions involved in the oxidative functionalization of C_sp³-H bonds adjacent to nitrogen atoms in N-aryl glycine esters were developed. The method provided rapid access to a variety of highly functionalized β-hydroxyl-α-amino acid derivatives from simple starting materials under mild conditions.

Original language	English
Pages (from-to)	11831-11833
Number of pages	3
Journal	Chemical Communications
Volume	52
Issue number	79
DOIs	https://doi.org/10.1039/c6cc04710f
State	Published - 2016

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title = "Enantioselective oxidative functionalization of the Csp3-H bond adjacent to a nitrogen atom for rapid access to β-hydroxyl-α-amino acid derivatives",

abstract = "Highly chemoselective and enantioselective one-pot reactions involved in the oxidative functionalization of Csp3-H bonds adjacent to nitrogen atoms in N-aryl glycine esters were developed. The method provided rapid access to a variety of highly functionalized β-hydroxyl-α-amino acid derivatives from simple starting materials under mild conditions.",

author = "Lin Qiu and Xin Guo and Yu Qian and Changcheng Jing and Chaoqun Ma and Shunying Liu and Wenhao Hu",

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year = "2016",

doi = "10.1039/c6cc04710f",

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T1 - Enantioselective oxidative functionalization of the Csp3-H bond adjacent to a nitrogen atom for rapid access to β-hydroxyl-α-amino acid derivatives

AU - Qiu, Lin

AU - Guo, Xin

AU - Qian, Yu

AU - Jing, Changcheng

AU - Ma, Chaoqun

AU - Liu, Shunying

AU - Hu, Wenhao

PY - 2016

Y1 - 2016

N2 - Highly chemoselective and enantioselective one-pot reactions involved in the oxidative functionalization of Csp3-H bonds adjacent to nitrogen atoms in N-aryl glycine esters were developed. The method provided rapid access to a variety of highly functionalized β-hydroxyl-α-amino acid derivatives from simple starting materials under mild conditions.

AB - Highly chemoselective and enantioselective one-pot reactions involved in the oxidative functionalization of Csp3-H bonds adjacent to nitrogen atoms in N-aryl glycine esters were developed. The method provided rapid access to a variety of highly functionalized β-hydroxyl-α-amino acid derivatives from simple starting materials under mild conditions.

UR - https://www.scopus.com/pages/publications/84989298187

U2 - 10.1039/c6cc04710f

DO - 10.1039/c6cc04710f

M3 - 文章

AN - SCOPUS:84989298187

SN - 1359-7345

VL - 52

SP - 11831

EP - 11833

JO - Chemical Communications

JF - Chemical Communications

IS - 79

ER -

Enantioselective oxidative functionalization of the C_sp³-H bond adjacent to a nitrogen atom for rapid access to β-hydroxyl-α-amino acid derivatives

Abstract

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