TY - JOUR
T1 - Emerging role of carboxylesterases in nonalcoholic fatty liver disease
AU - Liu, Jie
AU - Yao, Bingyi
AU - Gao, Liangcai
AU - Zhang, Yuanjin
AU - Huang, Shengbo
AU - Wang, Xin
N1 - Publisher Copyright:
© 2022 Elsevier Inc.
PY - 2022/11
Y1 - 2022/11
N2 - Nonalcoholic fatty liver disease (NAFLD) is increasingly recognized as a global public health problem. Carboxylesterases (CESs), as potential influencing factors of NAFLD, are very important to improve clinical outcomes. This review aims to deeply understand the role of CESs in the progression of NAFLD and proposes that CESs can be used as potential targets for NAFLD treatment. We first introduced CESs and analyzed the relationship between CESs and hepatic lipid metabolism and inflammation. Then, we further reviewed the regulation of nuclear receptors on CESs, including PXR, CAR, PPARα, HNF4α and FXR, which may influence the progression of NAFLD. Finally, we evaluated the advantages and disadvantages of existing NAFLD animal models and summarized the application of CES-related animal models in NAFLD research. In general, this review provides an overview of the relationship between CESs and NAFLD and discusses the role and potential value of CESs in the treatment and prevention of NAFLD.
AB - Nonalcoholic fatty liver disease (NAFLD) is increasingly recognized as a global public health problem. Carboxylesterases (CESs), as potential influencing factors of NAFLD, are very important to improve clinical outcomes. This review aims to deeply understand the role of CESs in the progression of NAFLD and proposes that CESs can be used as potential targets for NAFLD treatment. We first introduced CESs and analyzed the relationship between CESs and hepatic lipid metabolism and inflammation. Then, we further reviewed the regulation of nuclear receptors on CESs, including PXR, CAR, PPARα, HNF4α and FXR, which may influence the progression of NAFLD. Finally, we evaluated the advantages and disadvantages of existing NAFLD animal models and summarized the application of CES-related animal models in NAFLD research. In general, this review provides an overview of the relationship between CESs and NAFLD and discusses the role and potential value of CESs in the treatment and prevention of NAFLD.
KW - Animal models
KW - Carboxylesterases (CESs)
KW - Lipid metabolism
KW - Nonalcoholic fatty liver disease (NAFLD)
KW - Nuclear receptors
UR - https://www.scopus.com/pages/publications/85138555033
U2 - 10.1016/j.bcp.2022.115250
DO - 10.1016/j.bcp.2022.115250
M3 - 文献综述
C2 - 36130649
AN - SCOPUS:85138555033
SN - 0006-2952
VL - 205
JO - Biochemical Pharmacology
JF - Biochemical Pharmacology
M1 - 115250
ER -
