Electrochemical Synthesis of β-Keto Phosphorodithioates via Difunctionalization of Alkenes under Metal-Free Conditions

An efficient and green one-pot four-component strategy for the synthesis of β-keto phosphorodithioates via difunctionalization of alkenes using air as the oxygen source and cheap phosphorus pentasulfide (P₄S₁₀) as the sulfur and phosphorus source has been successfully reported at room temperature. This method features simple operation, mild conditions, step economy, wide range of substrates, and the avoidance of moisture-sensitive reagents/pre-functionalized substrates. These advantages of this electrochemical protocol are consistent with the concept of green synthetic chemistry, providing a straightforward and efficient pathway to synthesize β-keto phosphorodithioate derivatives.