Abstract
The determination of superoxide anion (O2•-) is of great physiological and pathological importance since O2 •- is considered to be involved in the etiology of aging, cancer, and progressive neurodegenerative diseases such as Parkinson's disease. The determination of the local concentration of O2•- has been a relatively challenging analytical problem because of the low concentration, high reactivity and short lifetime of O2 •- in biological systems. This review raises a number of methods, highlighting electrochemical methodologies, for the determination of O2•-. These electrochemical sensors and biosensors and their analytical characteristics are discussed in detail.
| Original language | English |
|---|---|
| Pages (from-to) | 51-58 |
| Number of pages | 8 |
| Journal | Current Analytical Chemistry |
| Volume | 2 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2006 |
| Externally published | Yes |
Keywords
- Cytochrome c
- Electrochemical biosensors
- In vivo
- Self-assembled monolayer (SAM)
- Superoxide anion (O)
- Superoxide dismutase (SOD)