Electrochemical biosensors for superoxide anion

Yang Tian, Lanqun Mao, Takeo Ohsaka

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

The determination of superoxide anion (O2•-) is of great physiological and pathological importance since O2 •- is considered to be involved in the etiology of aging, cancer, and progressive neurodegenerative diseases such as Parkinson's disease. The determination of the local concentration of O2•- has been a relatively challenging analytical problem because of the low concentration, high reactivity and short lifetime of O2 •- in biological systems. This review raises a number of methods, highlighting electrochemical methodologies, for the determination of O2•-. These electrochemical sensors and biosensors and their analytical characteristics are discussed in detail.

Original languageEnglish
Pages (from-to)51-58
Number of pages8
JournalCurrent Analytical Chemistry
Volume2
Issue number1
DOIs
StatePublished - Jan 2006
Externally publishedYes

Keywords

  • Cytochrome c
  • Electrochemical biosensors
  • In vivo
  • Self-assembled monolayer (SAM)
  • Superoxide anion (O)
  • Superoxide dismutase (SOD)

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