Electrochemical and spectroscopic studies on the interaction between copper(II) complex of Schiff base ligand and DNA

S. S. Zhang; S. Y. Niu; G. F. Jie; Y. Li; K. Jiao; F. Yang

Electrochemical and spectroscopic studies on the interaction between copper(II) complex of Schiff base ligand and DNA

S. S. Zhang^*
, S. Y. Niu
, G. F. Jie
, Y. Li
, K. Jiao
, F. Yang

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

Qingdao University of Science and Technology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

([CuL(C₆H₅N₂O₂) (ClO ₄)₂₇H₂O, CuL) (L = N-(5-sulfosalicylidene)- 4′-nitraniline) can strongly bind to DNA. The interaction between CuL and salmon sperm DNA in 0.1 mol L^-1 NaOAc-HOAc (pH 4.8) has been investigated by cyclic voltammetry and UV/Vis spectroscopy. The observed oxidative peak for the central copper ion of CuL from cyclic voltammogram is shown at the glassy carbon electrode. It has been found that the oxidative peak current decreased significantly with increasing concentrations of DNA. In addition, the absorbance of CuL at its absorption peaks also decreased in the presence of DNA. All experimental results indicate that CuL can bind to DNA to form a 1:1 association complex with the binding constant of 1.05 × 10 ⁵ L mol^-1, and the major binding mode of CuL to DNA is "electrostatic binding".

Original language	English
Pages (from-to)	393-397
Number of pages	5
Journal	Journal of the Indian Chemical Society
Volume	82
Issue number	5
State	Published - May 2005

Cite this

@article{fc4137afb9964fe9b4dc0d82e4161281,

title = "Electrochemical and spectroscopic studies on the interaction between copper(II) complex of Schiff base ligand and DNA",

abstract = "([CuL(C6H5N2O2) (ClO 4)27H2O, CuL) (L = N-(5-sulfosalicylidene)- 4′-nitraniline) can strongly bind to DNA. The interaction between CuL and salmon sperm DNA in 0.1 mol L-1 NaOAc-HOAc (pH 4.8) has been investigated by cyclic voltammetry and UV/Vis spectroscopy. The observed oxidative peak for the central copper ion of CuL from cyclic voltammogram is shown at the glassy carbon electrode. It has been found that the oxidative peak current decreased significantly with increasing concentrations of DNA. In addition, the absorbance of CuL at its absorption peaks also decreased in the presence of DNA. All experimental results indicate that CuL can bind to DNA to form a 1:1 association complex with the binding constant of 1.05 × 10 5 L mol-1, and the major binding mode of CuL to DNA is {"}electrostatic binding{"}.",

author = "Zhang, \{S. S.\} and Niu, \{S. Y.\} and Jie, \{G. F.\} and Y. Li and K. Jiao and F. Yang",

year = "2005",

month = may,

language = "英语",

volume = "82",

pages = "393--397",

journal = "Journal of the Indian Chemical Society",

issn = "0019-4522",

publisher = "Elsevier B.V.",

number = "5",

}

TY - JOUR

T1 - Electrochemical and spectroscopic studies on the interaction between copper(II) complex of Schiff base ligand and DNA

AU - Zhang, S. S.

AU - Niu, S. Y.

AU - Jie, G. F.

AU - Li, Y.

AU - Jiao, K.

AU - Yang, F.

PY - 2005/5

Y1 - 2005/5

N2 - ([CuL(C6H5N2O2) (ClO 4)27H2O, CuL) (L = N-(5-sulfosalicylidene)- 4′-nitraniline) can strongly bind to DNA. The interaction between CuL and salmon sperm DNA in 0.1 mol L-1 NaOAc-HOAc (pH 4.8) has been investigated by cyclic voltammetry and UV/Vis spectroscopy. The observed oxidative peak for the central copper ion of CuL from cyclic voltammogram is shown at the glassy carbon electrode. It has been found that the oxidative peak current decreased significantly with increasing concentrations of DNA. In addition, the absorbance of CuL at its absorption peaks also decreased in the presence of DNA. All experimental results indicate that CuL can bind to DNA to form a 1:1 association complex with the binding constant of 1.05 × 10 5 L mol-1, and the major binding mode of CuL to DNA is "electrostatic binding".

AB - ([CuL(C6H5N2O2) (ClO 4)27H2O, CuL) (L = N-(5-sulfosalicylidene)- 4′-nitraniline) can strongly bind to DNA. The interaction between CuL and salmon sperm DNA in 0.1 mol L-1 NaOAc-HOAc (pH 4.8) has been investigated by cyclic voltammetry and UV/Vis spectroscopy. The observed oxidative peak for the central copper ion of CuL from cyclic voltammogram is shown at the glassy carbon electrode. It has been found that the oxidative peak current decreased significantly with increasing concentrations of DNA. In addition, the absorbance of CuL at its absorption peaks also decreased in the presence of DNA. All experimental results indicate that CuL can bind to DNA to form a 1:1 association complex with the binding constant of 1.05 × 10 5 L mol-1, and the major binding mode of CuL to DNA is "electrostatic binding".

UR - https://www.scopus.com/pages/publications/20644469232

M3 - 文章

AN - SCOPUS:20644469232

SN - 0019-4522

VL - 82

SP - 393

EP - 397

JO - Journal of the Indian Chemical Society

JF - Journal of the Indian Chemical Society

IS - 5

ER -

Electrochemical and spectroscopic studies on the interaction between copper(II) complex of Schiff base ligand and DNA

Abstract

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