Efficient synthesis of vitamin D₃ in a 3D ultraviolet photochemical microreactor fabricated using an ultrafast laser

Large-scale, high-precision, and high-transparency microchannels hold great potential for developing high-performance continuous-flow photochemical reactions. We demonstrated ultrafast laser-enabled fabrication of three-dimensional microchannel reactors in ultraviolet (UV) grade fused silica which exhibit high transparency under the illumination of UV light sources of wavelengths well below 300 nm with excellent mixing efficiency. With the fabricated glass microchannel reactors, we demonstrated continuous-flow photochemical synthesis of vitamin D₃ with UV LED array light sources.