Efficient synthesis of α-aryl serine derivatives via three-component reactions of aryldiazoacetates, anilines and formaldehyde

Chengjin Wang; Shunying Liu; Dong Xing; Xin Wang; Xiang Wu; Wenhao Hu

doi:10.1016/j.tet.2013.10.046

Efficient synthesis of α-aryl serine derivatives via three-component reactions of aryldiazoacetates, anilines and formaldehyde

Chengjin Wang, Shunying Liu^*, Dong Xing, Xin Wang, Xiang Wu, Wenhao Hu

^*Corresponding author for this work

East China Normal University

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

A three-component reaction based on trapping of ammonium ylides with formaldehyde was first reported. This reaction offers a new strategy for the synthesis of α-aryl serine derivatives and can be extended to the preparation of α-aryl threonine derivatives. Synthetic application of the three component reaction for the preparation of hydroquinoxaline derivative was also demonstrated.

Original language	English
Pages (from-to)	11203-11208
Number of pages	6
Journal	Tetrahedron
Volume	69
Issue number	52
DOIs	https://doi.org/10.1016/j.tet.2013.10.046
State	Published - 30 Dec 2013

Keywords

Aldol-type reaction
Ammonium ylide
Formaldehyde
Three-component reaction
α-Aryl serine derivatives

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10.1016/j.tet.2013.10.046

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title = "Efficient synthesis of α-aryl serine derivatives via three-component reactions of aryldiazoacetates, anilines and formaldehyde",

abstract = "A three-component reaction based on trapping of ammonium ylides with formaldehyde was first reported. This reaction offers a new strategy for the synthesis of α-aryl serine derivatives and can be extended to the preparation of α-aryl threonine derivatives. Synthetic application of the three component reaction for the preparation of hydroquinoxaline derivative was also demonstrated.",

keywords = "Aldol-type reaction, Ammonium ylide, Formaldehyde, Three-component reaction, α-Aryl serine derivatives",

author = "Chengjin Wang and Shunying Liu and Dong Xing and Xin Wang and Xiang Wu and Wenhao Hu",

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T1 - Efficient synthesis of α-aryl serine derivatives via three-component reactions of aryldiazoacetates, anilines and formaldehyde

AU - Wang, Chengjin

AU - Liu, Shunying

AU - Xing, Dong

AU - Wang, Xin

AU - Wu, Xiang

AU - Hu, Wenhao

PY - 2013/12/30

Y1 - 2013/12/30

N2 - A three-component reaction based on trapping of ammonium ylides with formaldehyde was first reported. This reaction offers a new strategy for the synthesis of α-aryl serine derivatives and can be extended to the preparation of α-aryl threonine derivatives. Synthetic application of the three component reaction for the preparation of hydroquinoxaline derivative was also demonstrated.

AB - A three-component reaction based on trapping of ammonium ylides with formaldehyde was first reported. This reaction offers a new strategy for the synthesis of α-aryl serine derivatives and can be extended to the preparation of α-aryl threonine derivatives. Synthetic application of the three component reaction for the preparation of hydroquinoxaline derivative was also demonstrated.

KW - Aldol-type reaction

KW - Ammonium ylide

KW - Formaldehyde

KW - Three-component reaction

KW - α-Aryl serine derivatives

UR - https://www.scopus.com/pages/publications/84889578475

U2 - 10.1016/j.tet.2013.10.046

DO - 10.1016/j.tet.2013.10.046

M3 - 文章

AN - SCOPUS:84889578475

SN - 0040-4020

VL - 69

SP - 11203

EP - 11208

JO - Tetrahedron

JF - Tetrahedron

IS - 52

ER -

Efficient synthesis of α-aryl serine derivatives via three-component reactions of aryldiazoacetates, anilines and formaldehyde

Abstract

Keywords

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