TY - JOUR
T1 - Efficient analysis of metabolites of industrial additives in cerebrospinal fluids
AU - Jin, Ruihe
AU - Shi, Jun
AU - Yang, Jing
AU - Yin, Ge
AU - Xia, Chunjie
AU - Wang, Xiongwei
AU - Liu, Min
AU - Wu, Yan
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to Springer Nature Switzerland AG 2024.
PY - 2024/6
Y1 - 2024/6
N2 - Despite being protected by the blood–brain barrier and the blood–cerebrospinal fluid barrier, cerebrospinal fluids can contain contaminants that trigger neurotoxic effects, yet there are few effective methods to analyze metabolites of industrial additives. Here, we established a fast and robust analytical methodology, based on ultra-high performance liquid chromatography interfaced with triple quadrupole mass spectrometry, to quantitatively determine concentrations of metabolites of synthetic antioxidants, organophosphate esters, and phthalate esters in human cerebrospinal fluids. The developed method exhibited highly sensitive and stable instrumental performance, satisfactory recoveries, minimal matrix effects, and trace level detection limits. We identified and quantified thirty industrial additive metabolites in cerebrospinal fluid samples, at 0.58–13 ng/mL total concentrations.
AB - Despite being protected by the blood–brain barrier and the blood–cerebrospinal fluid barrier, cerebrospinal fluids can contain contaminants that trigger neurotoxic effects, yet there are few effective methods to analyze metabolites of industrial additives. Here, we established a fast and robust analytical methodology, based on ultra-high performance liquid chromatography interfaced with triple quadrupole mass spectrometry, to quantitatively determine concentrations of metabolites of synthetic antioxidants, organophosphate esters, and phthalate esters in human cerebrospinal fluids. The developed method exhibited highly sensitive and stable instrumental performance, satisfactory recoveries, minimal matrix effects, and trace level detection limits. We identified and quantified thirty industrial additive metabolites in cerebrospinal fluid samples, at 0.58–13 ng/mL total concentrations.
KW - Cerebral exposure
KW - Liquid chromatography–mass spectrometry
KW - Metabolic products
KW - Organophosphate esters
KW - Phthalate esters
KW - Synthetic antioxidants
UR - https://www.scopus.com/pages/publications/85185450392
U2 - 10.1007/s10311-024-01705-7
DO - 10.1007/s10311-024-01705-7
M3 - 文章
AN - SCOPUS:85185450392
SN - 1610-3653
VL - 22
SP - 997
EP - 1003
JO - Environmental Chemistry Letters
JF - Environmental Chemistry Letters
IS - 3
ER -