Efficient access to 1,4-benzothiazine: Palladium-catalyzed double C-S bond formation using Na2S2O3 as sulfurating reagent

Zongjun Qiao; Hui Liu; Xiao Xiao; Yana Fu; Jianpeng Wei; Yuxue Li; Xuefeng Jiang

doi:10.1021/ol400618k

Efficient access to 1,4-benzothiazine: Palladium-catalyzed double C-S bond formation using Na₂S₂O₃ as sulfurating reagent

Zongjun Qiao
, Hui Liu
, Xiao Xiao
, Yana Fu
, Jianpeng Wei
, Yuxue Li
, Xuefeng Jiang^*

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

East China Normal University
CAS - Shanghai Institute of Organic Chemistry

Research output: Contribution to journal › Article › peer-review

195 Scopus citations

Abstract

A novel Pd-catalyzed double C-S bond formation coupling reaction has been developed. This protocol, in which Na₂S₂O₃ was used as sulfurating reagent in metal-catalyzed reactions, provides an efficient method for the synthesis of substituted 1,4-benzothiazine derivates, which are structural elements of numerous bioactivity molecules rendering this protocol attractive to both synthetic and medicinal chemistry.

Original language	English
Pages (from-to)	2594-2597
Number of pages	4
Journal	Organic Letters
Volume	15
Issue number	11
DOIs	https://doi.org/10.1021/ol400618k
State	Published - 7 Jun 2013

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10.1021/ol400618k

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abstract = "A novel Pd-catalyzed double C-S bond formation coupling reaction has been developed. This protocol, in which Na2S2O3 was used as sulfurating reagent in metal-catalyzed reactions, provides an efficient method for the synthesis of substituted 1,4-benzothiazine derivates, which are structural elements of numerous bioactivity molecules rendering this protocol attractive to both synthetic and medicinal chemistry.",

author = "Zongjun Qiao and Hui Liu and Xiao Xiao and Yana Fu and Jianpeng Wei and Yuxue Li and Xuefeng Jiang",

year = "2013",

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journal = "Organic Letters",

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T1 - Efficient access to 1,4-benzothiazine

T2 - Palladium-catalyzed double C-S bond formation using Na2S2O3 as sulfurating reagent

AU - Qiao, Zongjun

AU - Liu, Hui

AU - Xiao, Xiao

AU - Fu, Yana

AU - Wei, Jianpeng

AU - Li, Yuxue

AU - Jiang, Xuefeng

PY - 2013/6/7

Y1 - 2013/6/7

N2 - A novel Pd-catalyzed double C-S bond formation coupling reaction has been developed. This protocol, in which Na2S2O3 was used as sulfurating reagent in metal-catalyzed reactions, provides an efficient method for the synthesis of substituted 1,4-benzothiazine derivates, which are structural elements of numerous bioactivity molecules rendering this protocol attractive to both synthetic and medicinal chemistry.

AB - A novel Pd-catalyzed double C-S bond formation coupling reaction has been developed. This protocol, in which Na2S2O3 was used as sulfurating reagent in metal-catalyzed reactions, provides an efficient method for the synthesis of substituted 1,4-benzothiazine derivates, which are structural elements of numerous bioactivity molecules rendering this protocol attractive to both synthetic and medicinal chemistry.

UR - https://www.scopus.com/pages/publications/84879200069

U2 - 10.1021/ol400618k

DO - 10.1021/ol400618k

M3 - 文章

AN - SCOPUS:84879200069

SN - 1523-7060

VL - 15

SP - 2594

EP - 2597

JO - Organic Letters

JF - Organic Letters

IS - 11

ER -

Efficient access to 1,4-benzothiazine: Palladium-catalyzed double C-S bond formation using Na₂S₂O₃ as sulfurating reagent

Abstract

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