Efficacy Evaluation of AAV2-EPO to Diabetic Retinopathy Based on Molecular Hyperspectral Imaging System

Liu Hongying; Fang Juan; Li QingLi; Zhang Jingfa

doi:10.1109/ICMTMA.2015.105

Efficacy Evaluation of AAV2-EPO to Diabetic Retinopathy Based on Molecular Hyperspectral Imaging System

Liu Hongying
, Fang Juan
, Li QingLi
, Zhang Jingfa

School of Communication and Electronic Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

AAV2-EPO (Adeno-associated virus type 2-mediated EPO) efficacy to early diabetic retinopathy (DR) of experimental rats was studied by molecular hyperspectral imaging system (MHIS). Molecular hyperspectral images of rat retinal tissue slice were collected in the normal control group N, the diabetic group D, the diabetes treatment group by AAV2-EPO (low dose group E1, middle dose group E2, high dose group E3). Raw data was pretreated by the obtained data model. By qualitative analysis of images and spectra, it were proves that AAV2-EPO has some efficacy to early diabetic retinopathy of rats. The experimental results show that AAV2-EPO treatment with middle dose can be most effective in reducing nerve cells apoptosis of retinal outer nuclear layer and have a certain effect to DR. Thus MHIS can help researchers exploring pathogenesis, causes of blindness and drug development of DR.

Original language	English
Title of host publication	Proceedings - 2015 7th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2015
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	411-414
Number of pages	4
ISBN (Electronic)	9781467371438
DOIs	https://doi.org/10.1109/ICMTMA.2015.105
State	Published - 11 Sep 2015
Event	7th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2015 - Nanchang, Jiangxi, China Duration: 13 Jun 2015 → 14 Jun 2015

Publication series

Name	Proceedings - 2015 7th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2015

Conference

Conference	7th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2015
Country/Territory	China
City	Nanchang, Jiangxi
Period	13/06/15 → 14/06/15

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

AAV2-EPO
Diabetic retinopathy
MHSI
ONL
Spectral Angle
qualitative analysis

Access to Document

10.1109/ICMTMA.2015.105

Cite this

Hongying, L., Juan, F., QingLi, L., & Jingfa, Z. (2015). Efficacy Evaluation of AAV2-EPO to Diabetic Retinopathy Based on Molecular Hyperspectral Imaging System. In Proceedings - 2015 7th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2015 (pp. 411-414). Article 7263598 (Proceedings - 2015 7th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2015). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ICMTMA.2015.105

Hongying, Liu ; Juan, Fang ; QingLi, Li et al. / Efficacy Evaluation of AAV2-EPO to Diabetic Retinopathy Based on Molecular Hyperspectral Imaging System. Proceedings - 2015 7th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2015. Institute of Electrical and Electronics Engineers Inc., 2015. pp. 411-414 (Proceedings - 2015 7th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2015).

@inproceedings{788a32a07bbb4409b0a1ef1461f1ff1f,

title = "Efficacy Evaluation of AAV2-EPO to Diabetic Retinopathy Based on Molecular Hyperspectral Imaging System",

abstract = "AAV2-EPO (Adeno-associated virus type 2-mediated EPO) efficacy to early diabetic retinopathy (DR) of experimental rats was studied by molecular hyperspectral imaging system (MHIS). Molecular hyperspectral images of rat retinal tissue slice were collected in the normal control group N, the diabetic group D, the diabetes treatment group by AAV2-EPO (low dose group E1, middle dose group E2, high dose group E3). Raw data was pretreated by the obtained data model. By qualitative analysis of images and spectra, it were proves that AAV2-EPO has some efficacy to early diabetic retinopathy of rats. The experimental results show that AAV2-EPO treatment with middle dose can be most effective in reducing nerve cells apoptosis of retinal outer nuclear layer and have a certain effect to DR. Thus MHIS can help researchers exploring pathogenesis, causes of blindness and drug development of DR.",

keywords = "AAV2-EPO, Diabetic retinopathy, MHSI, ONL, Spectral Angle, qualitative analysis",

author = "Liu Hongying and Fang Juan and Li QingLi and Zhang Jingfa",

note = "Publisher Copyright: {\textcopyright} 2015 IEEE.; 7th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2015 ; Conference date: 13-06-2015 Through 14-06-2015",

year = "2015",

month = sep,

day = "11",

doi = "10.1109/ICMTMA.2015.105",

language = "英语",

series = "Proceedings - 2015 7th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2015",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

pages = "411--414",

booktitle = "Proceedings - 2015 7th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2015",

address = "美国",

}

Hongying, L, Juan, F, QingLi, L & Jingfa, Z 2015, Efficacy Evaluation of AAV2-EPO to Diabetic Retinopathy Based on Molecular Hyperspectral Imaging System. in Proceedings - 2015 7th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2015., 7263598, Proceedings - 2015 7th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2015, Institute of Electrical and Electronics Engineers Inc., pp. 411-414, 7th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2015, Nanchang, Jiangxi, China, 13/06/15. https://doi.org/10.1109/ICMTMA.2015.105

Efficacy Evaluation of AAV2-EPO to Diabetic Retinopathy Based on Molecular Hyperspectral Imaging System. / Hongying, Liu; Juan, Fang; QingLi, Li et al.
Proceedings - 2015 7th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2015. Institute of Electrical and Electronics Engineers Inc., 2015. p. 411-414 7263598 (Proceedings - 2015 7th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2015).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Efficacy Evaluation of AAV2-EPO to Diabetic Retinopathy Based on Molecular Hyperspectral Imaging System

AU - Hongying, Liu

AU - Juan, Fang

AU - QingLi, Li

AU - Jingfa, Zhang

PY - 2015/9/11

Y1 - 2015/9/11

N2 - AAV2-EPO (Adeno-associated virus type 2-mediated EPO) efficacy to early diabetic retinopathy (DR) of experimental rats was studied by molecular hyperspectral imaging system (MHIS). Molecular hyperspectral images of rat retinal tissue slice were collected in the normal control group N, the diabetic group D, the diabetes treatment group by AAV2-EPO (low dose group E1, middle dose group E2, high dose group E3). Raw data was pretreated by the obtained data model. By qualitative analysis of images and spectra, it were proves that AAV2-EPO has some efficacy to early diabetic retinopathy of rats. The experimental results show that AAV2-EPO treatment with middle dose can be most effective in reducing nerve cells apoptosis of retinal outer nuclear layer and have a certain effect to DR. Thus MHIS can help researchers exploring pathogenesis, causes of blindness and drug development of DR.

AB - AAV2-EPO (Adeno-associated virus type 2-mediated EPO) efficacy to early diabetic retinopathy (DR) of experimental rats was studied by molecular hyperspectral imaging system (MHIS). Molecular hyperspectral images of rat retinal tissue slice were collected in the normal control group N, the diabetic group D, the diabetes treatment group by AAV2-EPO (low dose group E1, middle dose group E2, high dose group E3). Raw data was pretreated by the obtained data model. By qualitative analysis of images and spectra, it were proves that AAV2-EPO has some efficacy to early diabetic retinopathy of rats. The experimental results show that AAV2-EPO treatment with middle dose can be most effective in reducing nerve cells apoptosis of retinal outer nuclear layer and have a certain effect to DR. Thus MHIS can help researchers exploring pathogenesis, causes of blindness and drug development of DR.

KW - AAV2-EPO

KW - Diabetic retinopathy

KW - MHSI

KW - ONL

KW - Spectral Angle

KW - qualitative analysis

UR - https://www.scopus.com/pages/publications/84960130722

U2 - 10.1109/ICMTMA.2015.105

DO - 10.1109/ICMTMA.2015.105

M3 - 会议稿件

AN - SCOPUS:84960130722

T3 - Proceedings - 2015 7th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2015

SP - 411

EP - 414

BT - Proceedings - 2015 7th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2015

PB - Institute of Electrical and Electronics Engineers Inc.

T2 - 7th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2015

Y2 - 13 June 2015 through 14 June 2015

ER -

Hongying L, Juan F, QingLi L, Jingfa Z. Efficacy Evaluation of AAV2-EPO to Diabetic Retinopathy Based on Molecular Hyperspectral Imaging System. In Proceedings - 2015 7th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2015. Institute of Electrical and Electronics Engineers Inc. 2015. p. 411-414. 7263598. (Proceedings - 2015 7th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2015). doi: 10.1109/ICMTMA.2015.105

Efficacy Evaluation of AAV2-EPO to Diabetic Retinopathy Based on Molecular Hyperspectral Imaging System

Abstract

Publication series

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UN SDGs

Keywords

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