TY - GEN
T1 - Efficacy Evaluation of AAV2-EPO to Diabetic Retinopathy Based on Molecular Hyperspectral Imaging System
AU - Hongying, Liu
AU - Juan, Fang
AU - QingLi, Li
AU - Jingfa, Zhang
N1 - Publisher Copyright:
© 2015 IEEE.
PY - 2015/9/11
Y1 - 2015/9/11
N2 - AAV2-EPO (Adeno-associated virus type 2-mediated EPO) efficacy to early diabetic retinopathy (DR) of experimental rats was studied by molecular hyperspectral imaging system (MHIS). Molecular hyperspectral images of rat retinal tissue slice were collected in the normal control group N, the diabetic group D, the diabetes treatment group by AAV2-EPO (low dose group E1, middle dose group E2, high dose group E3). Raw data was pretreated by the obtained data model. By qualitative analysis of images and spectra, it were proves that AAV2-EPO has some efficacy to early diabetic retinopathy of rats. The experimental results show that AAV2-EPO treatment with middle dose can be most effective in reducing nerve cells apoptosis of retinal outer nuclear layer and have a certain effect to DR. Thus MHIS can help researchers exploring pathogenesis, causes of blindness and drug development of DR.
AB - AAV2-EPO (Adeno-associated virus type 2-mediated EPO) efficacy to early diabetic retinopathy (DR) of experimental rats was studied by molecular hyperspectral imaging system (MHIS). Molecular hyperspectral images of rat retinal tissue slice were collected in the normal control group N, the diabetic group D, the diabetes treatment group by AAV2-EPO (low dose group E1, middle dose group E2, high dose group E3). Raw data was pretreated by the obtained data model. By qualitative analysis of images and spectra, it were proves that AAV2-EPO has some efficacy to early diabetic retinopathy of rats. The experimental results show that AAV2-EPO treatment with middle dose can be most effective in reducing nerve cells apoptosis of retinal outer nuclear layer and have a certain effect to DR. Thus MHIS can help researchers exploring pathogenesis, causes of blindness and drug development of DR.
KW - AAV2-EPO
KW - Diabetic retinopathy
KW - MHSI
KW - ONL
KW - Spectral Angle
KW - qualitative analysis
UR - https://www.scopus.com/pages/publications/84960130722
U2 - 10.1109/ICMTMA.2015.105
DO - 10.1109/ICMTMA.2015.105
M3 - 会议稿件
AN - SCOPUS:84960130722
T3 - Proceedings - 2015 7th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2015
SP - 411
EP - 414
BT - Proceedings - 2015 7th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2015
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 7th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2015
Y2 - 13 June 2015 through 14 June 2015
ER -
