Effects of voltage trajectory on action potential voltage threshold in simulations of cat spinal motoneurons

Yue Dai; Kelvin E. Jones; Brent Fedirchuk; Larry M. Jordan

doi:10.1016/S0925-2312(00)00150-8

Effects of voltage trajectory on action potential voltage threshold in simulations of cat spinal motoneurons

Yue Dai, Kelvin E. Jones, Brent Fedirchuk, Larry M. Jordan

University of Manitoba

Research output: Contribution to journal › Conference article › peer-review

7 Scopus citations

Abstract

A single-cell neuronal model was used to investigate the effect of membrane trajectory on voltage threshold (V(th)) for action potential generation. Previous results suggested that hyperpolarization of V(th) could be produced by a rapid membrane depolarization, but this effect is limited to the first spike in a train. This study shows rapid current injections hyperpolarize V(th) because they are more effective in activating the sodium current underlying spiking. The hyperpolarization of V(th) induced by rapid membrane depolarization becomes less effective in altering V(th) when other mechanisms of enhancing the fast sodium current underlying action potentials are activated. (C) 2000 Published by Elsevier Science B.V. All rights reserved.

Original language	English
Pages (from-to)	105-111
Number of pages	7
Journal	Neurocomputing
Volume	32-33
DOIs	https://doi.org/10.1016/S0925-2312(00)00150-8
State	Published - Jun 2000
Externally published	Yes
Event	The 8th Annual Computational Neuroscience Meeting (CNS'99) - Pittsburgh, PA, USA Duration: 18 Jul 1999 → 22 Jul 1999

Keywords

Computer simulation
Fictive locomotion
Spike initiation
Voltage threshold

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10.1016/S0925-2312(00)00150-8

Cite this

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title = "Effects of voltage trajectory on action potential voltage threshold in simulations of cat spinal motoneurons",

abstract = "A single-cell neuronal model was used to investigate the effect of membrane trajectory on voltage threshold (V(th)) for action potential generation. Previous results suggested that hyperpolarization of V(th) could be produced by a rapid membrane depolarization, but this effect is limited to the first spike in a train. This study shows rapid current injections hyperpolarize V(th) because they are more effective in activating the sodium current underlying spiking. The hyperpolarization of V(th) induced by rapid membrane depolarization becomes less effective in altering V(th) when other mechanisms of enhancing the fast sodium current underlying action potentials are activated. (C) 2000 Published by Elsevier Science B.V. All rights reserved.",

keywords = "Computer simulation, Fictive locomotion, Spike initiation, Voltage threshold",

author = "Yue Dai and Jones, \{Kelvin E.\} and Brent Fedirchuk and Jordan, \{Larry M.\}",

year = "2000",

month = jun,

doi = "10.1016/S0925-2312(00)00150-8",

language = "英语",

volume = "32-33",

pages = "105--111",

journal = "Neurocomputing",

issn = "0925-2312",

publisher = "Elsevier B.V.",

note = "The 8th Annual Computational Neuroscience Meeting (CNS'99) ; Conference date: 18-07-1999 Through 22-07-1999",

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TY - JOUR

T1 - Effects of voltage trajectory on action potential voltage threshold in simulations of cat spinal motoneurons

AU - Dai, Yue

AU - Jones, Kelvin E.

AU - Fedirchuk, Brent

AU - Jordan, Larry M.

PY - 2000/6

Y1 - 2000/6

N2 - A single-cell neuronal model was used to investigate the effect of membrane trajectory on voltage threshold (V(th)) for action potential generation. Previous results suggested that hyperpolarization of V(th) could be produced by a rapid membrane depolarization, but this effect is limited to the first spike in a train. This study shows rapid current injections hyperpolarize V(th) because they are more effective in activating the sodium current underlying spiking. The hyperpolarization of V(th) induced by rapid membrane depolarization becomes less effective in altering V(th) when other mechanisms of enhancing the fast sodium current underlying action potentials are activated. (C) 2000 Published by Elsevier Science B.V. All rights reserved.

AB - A single-cell neuronal model was used to investigate the effect of membrane trajectory on voltage threshold (V(th)) for action potential generation. Previous results suggested that hyperpolarization of V(th) could be produced by a rapid membrane depolarization, but this effect is limited to the first spike in a train. This study shows rapid current injections hyperpolarize V(th) because they are more effective in activating the sodium current underlying spiking. The hyperpolarization of V(th) induced by rapid membrane depolarization becomes less effective in altering V(th) when other mechanisms of enhancing the fast sodium current underlying action potentials are activated. (C) 2000 Published by Elsevier Science B.V. All rights reserved.

KW - Computer simulation

KW - Fictive locomotion

KW - Spike initiation

KW - Voltage threshold

UR - https://www.scopus.com/pages/publications/18544401858

U2 - 10.1016/S0925-2312(00)00150-8

DO - 10.1016/S0925-2312(00)00150-8

M3 - 会议文章

AN - SCOPUS:18544401858

SN - 0925-2312

VL - 32-33

SP - 105

EP - 111

JO - Neurocomputing

JF - Neurocomputing

T2 - The 8th Annual Computational Neuroscience Meeting (CNS'99)

Y2 - 18 July 1999 through 22 July 1999

ER -

Effects of voltage trajectory on action potential voltage threshold in simulations of cat spinal motoneurons

Abstract

Keywords

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