TY - JOUR
T1 - Effects of treadmill exercise on β-amyloid precursor protein and Tau protein gene expressions in hippo- campus of D-galactose Alzheimer's disease rats
AU - Xu, Bo
AU - Yu, Feng
AU - Zhang, Xianliang
N1 - Publisher Copyright:
©, 2014, China-Japan Friendship Hospital. All right reserved.
PY - 2014/11/15
Y1 - 2014/11/15
N2 - Objective: To explore the effects of 8-week aerobic treadmill training on expressions of β-amyloid precursor protein (APP), Tau protein and glycogen synthase kinase-3β (GSK-3β) mRNA in hippocampus of D-galactose (D-gal) Alzheimer's disease (AD) rats. Method: Sixteen male Sprague-Dawley(SD) rats were randomly divided into control group (C, n=8), exercise group(T, n=8). All rats of two groups were injected D-gal 120mg/(kg· d) in abdominal for 8 weeks to obtain AD model rats. Group T was given aerobic treadmill, 5 times a week for 8 weeks. The expression levels of APP, Tau and GSK-3β in hippocampus of all rats were inspected by real-time fluorescence quantitative RT-PCR. Result: After 8- week aerobic treadmill exercise made the expressions of APP mRNA (42%, P<0.05), Tau mRNA (45%, P<0.01) and GSK-3β (38%, P<0.05) were down-regulated significantly in hippocampus of Dgal AD rats. Conclusion: Eight- week aerobic treadmill training could made some inhibition effects on the expressions of APP and Tau mRNA in D-gal AD rats. The mechanisms might be related with the lower expression level of GSK-3β mRNA, which was down-regulated by 8 weeks aerobic treadmill exercise and would made some important regulation effects on the levels of APP and Tau protein expression.
AB - Objective: To explore the effects of 8-week aerobic treadmill training on expressions of β-amyloid precursor protein (APP), Tau protein and glycogen synthase kinase-3β (GSK-3β) mRNA in hippocampus of D-galactose (D-gal) Alzheimer's disease (AD) rats. Method: Sixteen male Sprague-Dawley(SD) rats were randomly divided into control group (C, n=8), exercise group(T, n=8). All rats of two groups were injected D-gal 120mg/(kg· d) in abdominal for 8 weeks to obtain AD model rats. Group T was given aerobic treadmill, 5 times a week for 8 weeks. The expression levels of APP, Tau and GSK-3β in hippocampus of all rats were inspected by real-time fluorescence quantitative RT-PCR. Result: After 8- week aerobic treadmill exercise made the expressions of APP mRNA (42%, P<0.05), Tau mRNA (45%, P<0.01) and GSK-3β (38%, P<0.05) were down-regulated significantly in hippocampus of Dgal AD rats. Conclusion: Eight- week aerobic treadmill training could made some inhibition effects on the expressions of APP and Tau mRNA in D-gal AD rats. The mechanisms might be related with the lower expression level of GSK-3β mRNA, which was down-regulated by 8 weeks aerobic treadmill exercise and would made some important regulation effects on the levels of APP and Tau protein expression.
KW - Alzheimer's disease
KW - Amyloid precursor protein
KW - Glycogen synthase kinase-3β
KW - Tau protein
KW - Treadmill exercise
UR - https://www.scopus.com/pages/publications/84919833410
U2 - 10.3969/j.issn.1001-1242.2014.11.003
DO - 10.3969/j.issn.1001-1242.2014.11.003
M3 - 文章
AN - SCOPUS:84919833410
SN - 1001-1242
VL - 29
SP - 1010
EP - 1015
JO - Chinese Journal of Rehabilitation Medicine
JF - Chinese Journal of Rehabilitation Medicine
IS - 11
ER -