Abstract
Objective: To explore the effects of 8-week aerobic treadmill training on expressions of β-amyloid precursor protein (APP), Tau protein and glycogen synthase kinase-3β (GSK-3β) mRNA in hippocampus of D-galactose (D-gal) Alzheimer's disease (AD) rats.
Method: Sixteen male Sprague-Dawley(SD) rats were randomly divided into control group (C, n=8), exercise group(T, n=8). All rats of two groups were injected D-gal 120mg/(kg· d) in abdominal for 8 weeks to obtain AD model rats. Group T was given aerobic treadmill, 5 times a week for 8 weeks. The expression levels of APP, Tau and GSK-3β in hippocampus of all rats were inspected by real-time fluorescence quantitative RT-PCR.
Result: After 8- week aerobic treadmill exercise made the expressions of APP mRNA (42%, P<0.05), Tau mRNA (45%, P<0.01) and GSK-3β (38%, P<0.05) were down-regulated significantly in hippocampus of Dgal AD rats.
Conclusion: Eight- week aerobic treadmill training could made some inhibition effects on the expressions of APP and Tau mRNA in D-gal AD rats. The mechanisms might be related with the lower expression level of GSK-3β mRNA, which was down-regulated by 8 weeks aerobic treadmill exercise and would made some important regulation effects on the levels of APP and Tau protein expression.
| Original language | English |
|---|---|
| Pages (from-to) | 1010-1015 |
| Number of pages | 6 |
| Journal | Chinese Journal of Rehabilitation Medicine |
| Volume | 29 |
| Issue number | 11 |
| DOIs | |
| State | Published - 15 Nov 2014 |
| Externally published | Yes |
Keywords
- Alzheimer's disease
- Amyloid precursor protein
- Glycogen synthase kinase-3β
- Tau protein
- Treadmill exercise
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