TY - JOUR
T1 - Effects of atmospheric aging processes on in vitro induced oxidative stress and chemical composition of biomass burning aerosols
AU - Li, Jianjun
AU - Li, Jin
AU - Wang, Gehui
AU - Ho, Kin Fai
AU - Dai, Wenting
AU - Zhang, Ting
AU - Wang, Qiyuan
AU - Wu, Can
AU - Li, Lijuan
AU - Li, Li
AU - Zhang, Qi
N1 - Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2021/1/5
Y1 - 2021/1/5
N2 - Biomass burning (BB) has an important impact on local/regional air quality and human health in China, but most previous studies overlooked the influence of atmospheric aging processes on cytotoxicity and chemical composition of BB aerosols. In this study, we combined a combustion chamber and an oxidation flow reactor to generate fresh and aged BB PM2.5. Human bronchial epithelial BEAS-2B cells were exposed to PM2.5 preparation for 24 h, and then determined for particle-induced reactive oxygen species (ROS) in vitro. The particle-induced ROS production increased by 11 %–64 % after two days of aging, suggesting an enhancement of in vitro-induced oxidative stress (OS) of aged BB particles. Chemical analysis showed that organic matter (OM) was the dominant component with no changes in relative abundance for the fresh and aged BB particles. Organic polycyclic aromatic compounds and some metals showed strong correlations with ROS in fresh particles, indicating the important effects of these harmful components on the OS of fresh BB aerosols. However, such correlations were not found for the aged particles, which is possibly related to the loss of non- or low-toxic semivolatile compounds and the formation of secondary harmful OM (such as some N-containing organic compounds) during the atmospheric aging processes.
AB - Biomass burning (BB) has an important impact on local/regional air quality and human health in China, but most previous studies overlooked the influence of atmospheric aging processes on cytotoxicity and chemical composition of BB aerosols. In this study, we combined a combustion chamber and an oxidation flow reactor to generate fresh and aged BB PM2.5. Human bronchial epithelial BEAS-2B cells were exposed to PM2.5 preparation for 24 h, and then determined for particle-induced reactive oxygen species (ROS) in vitro. The particle-induced ROS production increased by 11 %–64 % after two days of aging, suggesting an enhancement of in vitro-induced oxidative stress (OS) of aged BB particles. Chemical analysis showed that organic matter (OM) was the dominant component with no changes in relative abundance for the fresh and aged BB particles. Organic polycyclic aromatic compounds and some metals showed strong correlations with ROS in fresh particles, indicating the important effects of these harmful components on the OS of fresh BB aerosols. However, such correlations were not found for the aged particles, which is possibly related to the loss of non- or low-toxic semivolatile compounds and the formation of secondary harmful OM (such as some N-containing organic compounds) during the atmospheric aging processes.
KW - Atmospheric aging
KW - Biomass burning aerosols
KW - Chemical composition
KW - Oxidative stress in vitro
UR - https://www.scopus.com/pages/publications/85090594935
U2 - 10.1016/j.jhazmat.2020.123750
DO - 10.1016/j.jhazmat.2020.123750
M3 - 文章
C2 - 33113732
AN - SCOPUS:85090594935
SN - 0304-3894
VL - 401
JO - Journal of Hazardous Materials
JF - Journal of Hazardous Materials
M1 - 123750
ER -
