TY - JOUR
T1 - Early deprivation reduced anxiety and enhanced memory in adult male rats
AU - Zhang, Xuliang
AU - Wang, Bo
AU - Jin, Jing
AU - An, Shuming
AU - Zeng, Qingwen
AU - Duan, Yanhong
AU - Yang, Liguo
AU - Ma, Jing
AU - Cao, Xiaohua
PY - 2014/9
Y1 - 2014/9
N2 - The effects of early deprivation (ED, which involves both dam and littermate deprivation) on anxiety and memory are less investigated in comparison with maternal separation (MS), and it is not yet clear how ED affects long-term potentiation (LTP) in the hippocampal Schaffer collateral pathway. By using a series of behavioral tests, enzyme-linked immunosorbent assay and field potential recording, we explored the effect of pre-weaning daily 3-h ED on anxiety, memory and potential mechanisms in adult male rats. Compared with control, ED rats spent longer time in open arms of elevated plus maze and in light compartment of light-dark transition box. Consistently, stress-induced blood plasma corticosterone level was also lower in ED rats. Moreover, ED rats showed better performance in social recognition and Morris water maze test. In accordance with results in memory tests, the threshold of LTP induction in hippocampal CA3-CA1 pathway of ED rats was also reduced. Our results indicate ED reduced anxiety, but enhanced social recognition and spatial reference memory. We suggest the diminished hypothalamic-pituitary-adrenal axis response and facilitated hippocampal LTP may contribute to the anxiety-reducing and memory-enhancing effects of ED, respectively.
AB - The effects of early deprivation (ED, which involves both dam and littermate deprivation) on anxiety and memory are less investigated in comparison with maternal separation (MS), and it is not yet clear how ED affects long-term potentiation (LTP) in the hippocampal Schaffer collateral pathway. By using a series of behavioral tests, enzyme-linked immunosorbent assay and field potential recording, we explored the effect of pre-weaning daily 3-h ED on anxiety, memory and potential mechanisms in adult male rats. Compared with control, ED rats spent longer time in open arms of elevated plus maze and in light compartment of light-dark transition box. Consistently, stress-induced blood plasma corticosterone level was also lower in ED rats. Moreover, ED rats showed better performance in social recognition and Morris water maze test. In accordance with results in memory tests, the threshold of LTP induction in hippocampal CA3-CA1 pathway of ED rats was also reduced. Our results indicate ED reduced anxiety, but enhanced social recognition and spatial reference memory. We suggest the diminished hypothalamic-pituitary-adrenal axis response and facilitated hippocampal LTP may contribute to the anxiety-reducing and memory-enhancing effects of ED, respectively.
KW - Anxiety
KW - Corticosterone
KW - Long-term potentiation
KW - Maternal deprivation
KW - Memory
UR - https://www.scopus.com/pages/publications/84906772045
U2 - 10.1016/j.brainresbull.2014.08.005
DO - 10.1016/j.brainresbull.2014.08.005
M3 - 文章
C2 - 25157962
AN - SCOPUS:84906772045
SN - 0361-9230
VL - 108
SP - 44
EP - 50
JO - Brain Research Bulletin
JF - Brain Research Bulletin
ER -