TY - JOUR
T1 - Dynamic Covalent Cage
T2 - A Selective and Robust Fluorescence Sensor for Copper Ion Detection in Aqueous Solutions
AU - Drożdż, Wojciech
AU - Liu, Chao
AU - Yu, Chengzhong
AU - Stefankiewicz, Artur R.
N1 - Publisher Copyright:
© 2025 The Author(s). Small Structures published by Wiley-VCH GmbH.
PY - 2025/11
Y1 - 2025/11
N2 - The development of advanced sensing systems for the selective detection of metal ions, such as copper (Cu2+), is a pressing challenge in modern analytical and environmental chemistry due to their dual role as essential elements in biological systems and potential toxins at elevated concentrations. Herein, a novel fluorescent organic cage based on a triphenylamine (TPA) chromophore is introduced, designed specifically for the detection of Cu2+ ions in water. The design concept involves the incorporation of two dynamic covalent bonds: acylhydrazone and disulfide, within a single cage structure, imparting adaptability and exceptional sensing performance. This cage demonstrates a distinct “turn-off” fluorescence response, with a pronounced signal decrease upon Cu2+ binding, offering reliable and accurate quantitative detection. Additionally, the system provides qualitative, visible colorimetric responsivity, enabling straightforward, visual detection without the need for advanced instrumentation. Its high selectivity toward Cu2+, combined with a low detection limit of 4.75 μM, ensures precise analysis even in the presence of competing metal ions. Practical applicability is demonstrated through the successful detection of Cu2+ in real water samples, highlighting the system's potential for environmental monitoring and field application.
AB - The development of advanced sensing systems for the selective detection of metal ions, such as copper (Cu2+), is a pressing challenge in modern analytical and environmental chemistry due to their dual role as essential elements in biological systems and potential toxins at elevated concentrations. Herein, a novel fluorescent organic cage based on a triphenylamine (TPA) chromophore is introduced, designed specifically for the detection of Cu2+ ions in water. The design concept involves the incorporation of two dynamic covalent bonds: acylhydrazone and disulfide, within a single cage structure, imparting adaptability and exceptional sensing performance. This cage demonstrates a distinct “turn-off” fluorescence response, with a pronounced signal decrease upon Cu2+ binding, offering reliable and accurate quantitative detection. Additionally, the system provides qualitative, visible colorimetric responsivity, enabling straightforward, visual detection without the need for advanced instrumentation. Its high selectivity toward Cu2+, combined with a low detection limit of 4.75 μM, ensures precise analysis even in the presence of competing metal ions. Practical applicability is demonstrated through the successful detection of Cu2+ in real water samples, highlighting the system's potential for environmental monitoring and field application.
KW - fluorescence quenching
KW - qualitative and visual identification
KW - selective copper detection
KW - water-soluble organic cages
UR - https://www.scopus.com/pages/publications/105016680352
U2 - 10.1002/sstr.202500216
DO - 10.1002/sstr.202500216
M3 - 文章
AN - SCOPUS:105016680352
SN - 2688-4062
VL - 6
JO - Small Structures
JF - Small Structures
IS - 11
M1 - 2500216
ER -