Abstract
Drug innovation is not only reflected in the discovery of new chemotypes of active compounds against existing targets but also more dependent on the innovation of drug targets. Currently, a number of attractive and validated targets could not be targeted pharmacologically. Some have been described as “undruggable”. In this review, we summarized the current situation of “undruggable” targets, and the design strategies for “undruggable” targets, hoping to provide references for the development of innovative drugs.
| Original language | English |
|---|---|
| Pages (from-to) | 501-512 |
| Number of pages | 12 |
| Journal | Chinese Journal of Chemistry |
| Volume | 37 |
| Issue number | 5 |
| DOIs | |
| State | Published - 1 May 2019 |
| Externally published | Yes |
Keywords
- RAS
- RNA
- drug design
- phosphatases
- protein-protein interactions
- transcription factors
- “undruggable” targets