DNA sensor based on functionalized polypyrrole

Jadranka Travas-Sejdic; Hui Peng; Paul A. Kilmaitin; Mark B. Cannell; G. A. Bowmaker; Ralph P. Cooney; Christian Soeller

doi:10.1016/j.synthmet.2005.07.103

DNA sensor based on functionalized polypyrrole

Jadranka Travas-Sejdic^*, Hui Peng, Paul A. Kilmaitin, Mark B. Cannell, G. A. Bowmaker, Ralph P. Cooney, Christian Soeller

^*Corresponding author for this work

The University of Auckland

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

A novel DNA sensor based on a functionalized polypyrrole was prepared. The sensor film was obtained by electrocopolymerizing poly(pyrrole-co-4-(3-pyrrolyl) butanoic acid) onto which an NH₂-ODN probe was grafted. The obtained sensor is a simple, label-free DNA sensor with direct electrical read-out. Hybridisation with complementary ODN was investigated by observing changes in die cyclic voltammogram and the AC impedance spectrum. Significant modifications of both the voltammogram and AC impedance spectrum were observed when the sensor was incubated in the presence of complementary ODN. The AC impedance spectra show an increased charge transfer resistance of the film after hybridisation.

Original language	English
Pages (from-to)	37-40
Number of pages	4
Journal	Synthetic Metals
Volume	152
Issue number	1-3
DOIs	https://doi.org/10.1016/j.synthmet.2005.07.103
State	Published - 20 Sep 2005
Externally published	Yes

Keywords

AC impedance
Cyclic volammetry
DNA sensor
Polypyrrole derivative

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10.1016/j.synthmet.2005.07.103

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title = "DNA sensor based on functionalized polypyrrole",

abstract = "A novel DNA sensor based on a functionalized polypyrrole was prepared. The sensor film was obtained by electrocopolymerizing poly(pyrrole-co-4-(3-pyrrolyl) butanoic acid) onto which an NH2-ODN probe was grafted. The obtained sensor is a simple, label-free DNA sensor with direct electrical read-out. Hybridisation with complementary ODN was investigated by observing changes in die cyclic voltammogram and the AC impedance spectrum. Significant modifications of both the voltammogram and AC impedance spectrum were observed when the sensor was incubated in the presence of complementary ODN. The AC impedance spectra show an increased charge transfer resistance of the film after hybridisation.",

keywords = "AC impedance, Cyclic volammetry, DNA sensor, Polypyrrole derivative",

author = "Jadranka Travas-Sejdic and Hui Peng and Kilmaitin, \{Paul A.\} and Cannell, \{Mark B.\} and Bowmaker, \{G. A.\} and Cooney, \{Ralph P.\} and Christian Soeller",

year = "2005",

month = sep,

day = "20",

doi = "10.1016/j.synthmet.2005.07.103",

language = "英语",

volume = "152",

pages = "37--40",

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publisher = "Elsevier B.V.",

number = "1-3",

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TY - JOUR

T1 - DNA sensor based on functionalized polypyrrole

AU - Travas-Sejdic, Jadranka

AU - Peng, Hui

AU - Kilmaitin, Paul A.

AU - Cannell, Mark B.

AU - Bowmaker, G. A.

AU - Cooney, Ralph P.

AU - Soeller, Christian

PY - 2005/9/20

Y1 - 2005/9/20

N2 - A novel DNA sensor based on a functionalized polypyrrole was prepared. The sensor film was obtained by electrocopolymerizing poly(pyrrole-co-4-(3-pyrrolyl) butanoic acid) onto which an NH2-ODN probe was grafted. The obtained sensor is a simple, label-free DNA sensor with direct electrical read-out. Hybridisation with complementary ODN was investigated by observing changes in die cyclic voltammogram and the AC impedance spectrum. Significant modifications of both the voltammogram and AC impedance spectrum were observed when the sensor was incubated in the presence of complementary ODN. The AC impedance spectra show an increased charge transfer resistance of the film after hybridisation.

AB - A novel DNA sensor based on a functionalized polypyrrole was prepared. The sensor film was obtained by electrocopolymerizing poly(pyrrole-co-4-(3-pyrrolyl) butanoic acid) onto which an NH2-ODN probe was grafted. The obtained sensor is a simple, label-free DNA sensor with direct electrical read-out. Hybridisation with complementary ODN was investigated by observing changes in die cyclic voltammogram and the AC impedance spectrum. Significant modifications of both the voltammogram and AC impedance spectrum were observed when the sensor was incubated in the presence of complementary ODN. The AC impedance spectra show an increased charge transfer resistance of the film after hybridisation.

KW - AC impedance

KW - Cyclic volammetry

KW - DNA sensor

KW - Polypyrrole derivative

UR - https://www.scopus.com/pages/publications/24644470159

U2 - 10.1016/j.synthmet.2005.07.103

DO - 10.1016/j.synthmet.2005.07.103

M3 - 文章

AN - SCOPUS:24644470159

SN - 0379-6779

VL - 152

SP - 37

EP - 40

JO - Synthetic Metals

JF - Synthetic Metals

IS - 1-3

ER -

DNA sensor based on functionalized polypyrrole

Abstract

Keywords

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