DNA Functionalized Fluorescent Quantum Dots for Bioanalytical Applications

As a newly developed fluorescent probe, DNA functionalized quantum dots (QDs) with unique optical properties play a critical role in the bioanalytical applications. The present review provides an overview on the conjugation technologies of DNA to QDs, including electrostatic attraction, covalent attachment, specific effect and direct synthesis. In addition, we summarize recent advances on DNA functionalized QDs in the bioapplications, such as targeting nucleic acids, ions, small molecules and the protein detection, cell imaging and disease diagnosis. Finally, we envision aspects concerning current challenges on the DNA functionalized fluorescent QDs.