DNA-Based Chemical Reaction Networks

Motivated by complex molecular networks of biological organisms, which enable control of the temporal and spatial concentrations of molecules, the bottom-up development of artificial chemical reaction networks has received renewed interest from biochemists. Based on hybridization and strand-displacement reactions, DNA-based chemical reaction networks (D-CRNs) provide a promising method to describe and analyze (bio)chemical systems, depending on their high programmability and directionality. Herein, progress in the development of D-CRNs is discussed, and an overview of significant biochemistry applications based on D-CRNs reported in recent decades is provided. Furthermore, opportunities and future directions for research into D-CRNs in biochemistry are also discussed.