Diazo compounds-involved catalytic asymmetric multicomponent reactions

This accounts covers the recent advances in diazo compounds-involved catalytic asymmetric multicomponent reactions developed by our research group. Based on the electrophilic trapping of active oxonium ylides, ammonium ylides or zwitterionic intermediates that generated from diazo compounds via metal carbenes, an array of catalytic asymmetric multicomponent reactions have been developed. Cooperative catalytic strategies have been applied to control enantioselectivity of the reactions. These transformations offer efficient and powerful strategies for the synthesis of polyfunctional chiral molecules.