Developmentally degraded cortical temporal processing restored by training

Xiaoming Zhou; Michael M. Merzenich

doi:10.1038/nn.2239

Developmentally degraded cortical temporal processing restored by training

Xiaoming Zhou^*
, Michael M. Merzenich

^*Corresponding author for this work

School of Life Sciences

University of California at San Francisco

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

Enduring deficits in temporal processing can be induced in the auditory cortex by rearing infant rats in the presence of low frequency-modulated noises. We found that it was possible to restore normal temporal processing, overcoming deficits induced during the critical period, by intensively training developmentally impaired animals as juveniles or young adults. Re-normalized cortical temporal response characteristics were sustained long after training cessation.

Original language	English
Pages (from-to)	26-28
Number of pages	3
Journal	Nature Neuroscience
Volume	12
Issue number	1
DOIs	https://doi.org/10.1038/nn.2239
State	Published - Jan 2009

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abstract = "Enduring deficits in temporal processing can be induced in the auditory cortex by rearing infant rats in the presence of low frequency-modulated noises. We found that it was possible to restore normal temporal processing, overcoming deficits induced during the critical period, by intensively training developmentally impaired animals as juveniles or young adults. Re-normalized cortical temporal response characteristics were sustained long after training cessation.",

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AB - Enduring deficits in temporal processing can be induced in the auditory cortex by rearing infant rats in the presence of low frequency-modulated noises. We found that it was possible to restore normal temporal processing, overcoming deficits induced during the critical period, by intensively training developmentally impaired animals as juveniles or young adults. Re-normalized cortical temporal response characteristics were sustained long after training cessation.

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Developmentally degraded cortical temporal processing restored by training

Abstract

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