Determination of organophosphate and carbamate pesticides based on enzyme inhibition using a pH-sensitive fluorescence probe

Shengye Jin, Zhaochao Xu, Jiping Chen*, Xinmiao Liang, Yongning Wu, Xuhong Qian

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

101 Scopus citations

Abstract

A flow injection system for the determination of organophosphate and carbamate pesticides is described. A sensitive fluorescence probe was synthesized and used as the pH indicator to detect the inhibition of the enzyme acetylcholinesterase (AChE). The percentage inhibition of enzyme activity is correlated to the pesticide concentration. Several parameters influencing the performance of the system are discussed. The detection limits of 3.5, 50, 12 and 25 μg/l for carbofuran, carbaryl, paraoxon and dichlorvos, in pure water, respectively were achieved with an incubation time of 10 min. A complete cycle of analysis, including incubation time, took 14 min. The detection system has been applied to the determination of carbofuran in spiked vegetable juices (Chinese cabbage and cole), achieving recovery values between 93.2 and 107% for Chinese cabbage juice and 108 and 118% for cole juice at the different concentration levels assayed.

Original languageEnglish
Pages (from-to)117-123
Number of pages7
JournalAnalytica Chimica Acta
Volume523
Issue number1
DOIs
StatePublished - 4 Oct 2004
Externally publishedYes

Keywords

  • Acetylcholinesterase
  • Carbamate pesticides
  • Flow-injection analysis
  • Fluorescence probe
  • Organophosphate pesticides
  • Vegetable juices

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