Determination of dissociation constants of anthrocycline by capillary zone electrophoresis with amperometric detection

Qin Hu; Gang Hu; Tianshu Zhou; Yuzhi Fang

doi:10.1016/S0731-7085(02)00681-7

Determination of dissociation constants of anthrocycline by capillary zone electrophoresis with amperometric detection

Qin Hu
, Gang Hu
, Tianshu Zhou
, Yuzhi Fang^*

^*Corresponding author for this work

School of Ecology and Environmental Sciences

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Although daunorubicin, pharmorubicin and idarubicin are important drugs in medical and in pharmaceutical research, the dissociation constants (K_a) of these substances are frequently not known. A method based on a non-linear model enabling the efficient determination of the K_a of the three drugs by capillary zone electrophoresis with amperometric detection (CZE-AD) has been demonstrated. The pK_a values obtained through the method were in agreement with the values by typical spectrophotometric method.

Original language	English
Pages (from-to)	679-684
Number of pages	6
Journal	Journal of Pharmaceutical and Biomedical Analysis
Volume	31
Issue number	4
DOIs	https://doi.org/10.1016/S0731-7085(02)00681-7
State	Published - 26 Mar 2003

Keywords

Anthrocycline
Capillary zone electrophoresis
Dissociation constant
Electrochemical detection

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10.1016/S0731-7085(02)00681-7

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title = "Determination of dissociation constants of anthrocycline by capillary zone electrophoresis with amperometric detection",

abstract = "Although daunorubicin, pharmorubicin and idarubicin are important drugs in medical and in pharmaceutical research, the dissociation constants (Ka) of these substances are frequently not known. A method based on a non-linear model enabling the efficient determination of the Ka of the three drugs by capillary zone electrophoresis with amperometric detection (CZE-AD) has been demonstrated. The pKa values obtained through the method were in agreement with the values by typical spectrophotometric method.",

keywords = "Anthrocycline, Capillary zone electrophoresis, Dissociation constant, Electrochemical detection",

author = "Qin Hu and Gang Hu and Tianshu Zhou and Yuzhi Fang",

year = "2003",

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T1 - Determination of dissociation constants of anthrocycline by capillary zone electrophoresis with amperometric detection

AU - Hu, Qin

AU - Hu, Gang

AU - Zhou, Tianshu

AU - Fang, Yuzhi

PY - 2003/3/26

Y1 - 2003/3/26

N2 - Although daunorubicin, pharmorubicin and idarubicin are important drugs in medical and in pharmaceutical research, the dissociation constants (Ka) of these substances are frequently not known. A method based on a non-linear model enabling the efficient determination of the Ka of the three drugs by capillary zone electrophoresis with amperometric detection (CZE-AD) has been demonstrated. The pKa values obtained through the method were in agreement with the values by typical spectrophotometric method.

AB - Although daunorubicin, pharmorubicin and idarubicin are important drugs in medical and in pharmaceutical research, the dissociation constants (Ka) of these substances are frequently not known. A method based on a non-linear model enabling the efficient determination of the Ka of the three drugs by capillary zone electrophoresis with amperometric detection (CZE-AD) has been demonstrated. The pKa values obtained through the method were in agreement with the values by typical spectrophotometric method.

KW - Anthrocycline

KW - Capillary zone electrophoresis

KW - Dissociation constant

KW - Electrochemical detection

UR - https://www.scopus.com/pages/publications/0037467188

U2 - 10.1016/S0731-7085(02)00681-7

DO - 10.1016/S0731-7085(02)00681-7

M3 - 文章

C2 - 12644194

AN - SCOPUS:0037467188

SN - 0731-7085

VL - 31

SP - 679

EP - 684

JO - Journal of Pharmaceutical and Biomedical Analysis

JF - Journal of Pharmaceutical and Biomedical Analysis

IS - 4

ER -

Determination of dissociation constants of anthrocycline by capillary zone electrophoresis with amperometric detection

Abstract

Keywords

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