Design and synthesis of matrix metalloprotease photoaffinity trimodular probes

Wenwei Qiu; Jie Xu; Xin Li; Li Zhong; Jingya Li; Jia Li; Fajun Nan

doi:10.1002/cjoc.200990138

Design and synthesis of matrix metalloprotease photoaffinity trimodular probes

Wenwei Qiu
, Jie Xu
, Xin Li
, Li Zhong
, Jingya Li
, Jia Li
, Fajun Nan^*

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

CAS - Shanghai Institute of Materia Medica

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

To explore the molecular mechanism of the matrix metalloproteinases (MMPs) in tumor processes, two photoaffinity trimodular probes were designed and synthesized based on the structure activity relationship and the following photoaffinity labelling experiments afforded positive results.

Original language	English
Pages (from-to)	825-833
Number of pages	9
Journal	Chinese Journal of Chemistry
Volume	27
Issue number	4
DOIs	https://doi.org/10.1002/cjoc.200990138
State	Published - Apr 2009

Keywords

Click chemistry
Matrix metalloprotease
Photoaffinity labeling
Protein profiling
Trimodular probe

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10.1002/cjoc.200990138

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@article{3b5fe17415814d65a00b92b1ccfb14ea,

title = "Design and synthesis of matrix metalloprotease photoaffinity trimodular probes",

abstract = "To explore the molecular mechanism of the matrix metalloproteinases (MMPs) in tumor processes, two photoaffinity trimodular probes were designed and synthesized based on the structure activity relationship and the following photoaffinity labelling experiments afforded positive results.",

keywords = "Click chemistry, Matrix metalloprotease, Photoaffinity labeling, Protein profiling, Trimodular probe",

author = "Wenwei Qiu and Jie Xu and Xin Li and Li Zhong and Jingya Li and Jia Li and Fajun Nan",

year = "2009",

month = apr,

doi = "10.1002/cjoc.200990138",

language = "英语",

volume = "27",

pages = "825--833",

journal = "Chinese Journal of Chemistry",

issn = "1001-604X",

publisher = "John Wiley and Sons Inc",

number = "4",

}

TY - JOUR

T1 - Design and synthesis of matrix metalloprotease photoaffinity trimodular probes

AU - Qiu, Wenwei

AU - Xu, Jie

AU - Li, Xin

AU - Zhong, Li

AU - Li, Jingya

AU - Li, Jia

AU - Nan, Fajun

PY - 2009/4

Y1 - 2009/4

N2 - To explore the molecular mechanism of the matrix metalloproteinases (MMPs) in tumor processes, two photoaffinity trimodular probes were designed and synthesized based on the structure activity relationship and the following photoaffinity labelling experiments afforded positive results.

AB - To explore the molecular mechanism of the matrix metalloproteinases (MMPs) in tumor processes, two photoaffinity trimodular probes were designed and synthesized based on the structure activity relationship and the following photoaffinity labelling experiments afforded positive results.

KW - Click chemistry

KW - Matrix metalloprotease

KW - Photoaffinity labeling

KW - Protein profiling

KW - Trimodular probe

UR - https://www.scopus.com/pages/publications/67449143448

U2 - 10.1002/cjoc.200990138

DO - 10.1002/cjoc.200990138

M3 - 文章

AN - SCOPUS:67449143448

SN - 1001-604X

VL - 27

SP - 825

EP - 833

JO - Chinese Journal of Chemistry

JF - Chinese Journal of Chemistry

IS - 4

ER -

Design and synthesis of matrix metalloprotease photoaffinity trimodular probes

Abstract

Keywords

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