Cycloartane triterpenoids from the stems of Schisandra glaucescens and their bioactivity

Juan Zou; Jing Jiang; Yan Yan Diao; Li Bin Yang; Jin Huang; Hong Lin Li; Xue Du; Wei Lie Xiao; Jian Xin Pu; Han Dong Sun

doi:10.1016/j.fitote.2012.04.007

Cycloartane triterpenoids from the stems of Schisandra glaucescens and their bioactivity

Juan Zou
, Jing Jiang
, Yan Yan Diao
, Li Bin Yang
, Jin Huang
, Hong Lin Li
, Xue Du
, Wei Lie Xiao^*
, Jian Xin Pu
, Han Dong Sun

^*Corresponding author for this work

CAS - Kunming Institute of Botany
University of Chinese Academy of Sciences
East China University of Science and Technology

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Five new cycloartane triterpenoids, schiglausins K-O (1-5), including one hexanortriterpenoid (1) and one octanortriterpenoid (2), as well as two known compounds (6-7), were isolated from the stems of Schisandra glaucescens Diels. Their structures were elucidated on the basis of spectroscopic methods, including extensive NMR spectra. Compounds 2-7 were tested for their FXR agonistic and antagonistic effects. Compound 7 exhibited significant antagonistic effect against FXR with IC ₅₀ of 1.50 μM.

Original language	English
Pages (from-to)	926-931
Number of pages	6
Journal	Fitoterapia
Volume	83
Issue number	5
DOIs	https://doi.org/10.1016/j.fitote.2012.04.007
State	Published - Jul 2012
Externally published	Yes

Keywords

Cycloartane triterpenoid
FXR agonistic and antagonistic effects
Schisandra glaucescens
Schisandraceae

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10.1016/j.fitote.2012.04.007

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title = "Cycloartane triterpenoids from the stems of Schisandra glaucescens and their bioactivity",

abstract = "Five new cycloartane triterpenoids, schiglausins K-O (1-5), including one hexanortriterpenoid (1) and one octanortriterpenoid (2), as well as two known compounds (6-7), were isolated from the stems of Schisandra glaucescens Diels. Their structures were elucidated on the basis of spectroscopic methods, including extensive NMR spectra. Compounds 2-7 were tested for their FXR agonistic and antagonistic effects. Compound 7 exhibited significant antagonistic effect against FXR with IC 50 of 1.50 μM.",

keywords = "Cycloartane triterpenoid, FXR agonistic and antagonistic effects, Schisandra glaucescens, Schisandraceae",

author = "Juan Zou and Jing Jiang and Diao, \{Yan Yan\} and Yang, \{Li Bin\} and Jin Huang and Li, \{Hong Lin\} and Xue Du and Xiao, \{Wei Lie\} and Pu, \{Jian Xin\} and Sun, \{Han Dong\}",

year = "2012",

month = jul,

doi = "10.1016/j.fitote.2012.04.007",

language = "英语",

volume = "83",

pages = "926--931",

journal = "Fitoterapia",

issn = "0367-326X",

publisher = "Elsevier B.V.",

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}

TY - JOUR

T1 - Cycloartane triterpenoids from the stems of Schisandra glaucescens and their bioactivity

AU - Zou, Juan

AU - Jiang, Jing

AU - Diao, Yan Yan

AU - Yang, Li Bin

AU - Huang, Jin

AU - Li, Hong Lin

AU - Du, Xue

AU - Xiao, Wei Lie

AU - Pu, Jian Xin

AU - Sun, Han Dong

PY - 2012/7

Y1 - 2012/7

N2 - Five new cycloartane triterpenoids, schiglausins K-O (1-5), including one hexanortriterpenoid (1) and one octanortriterpenoid (2), as well as two known compounds (6-7), were isolated from the stems of Schisandra glaucescens Diels. Their structures were elucidated on the basis of spectroscopic methods, including extensive NMR spectra. Compounds 2-7 were tested for their FXR agonistic and antagonistic effects. Compound 7 exhibited significant antagonistic effect against FXR with IC 50 of 1.50 μM.

AB - Five new cycloartane triterpenoids, schiglausins K-O (1-5), including one hexanortriterpenoid (1) and one octanortriterpenoid (2), as well as two known compounds (6-7), were isolated from the stems of Schisandra glaucescens Diels. Their structures were elucidated on the basis of spectroscopic methods, including extensive NMR spectra. Compounds 2-7 were tested for their FXR agonistic and antagonistic effects. Compound 7 exhibited significant antagonistic effect against FXR with IC 50 of 1.50 μM.

KW - Cycloartane triterpenoid

KW - FXR agonistic and antagonistic effects

KW - Schisandra glaucescens

KW - Schisandraceae

UR - https://www.scopus.com/pages/publications/84861597812

U2 - 10.1016/j.fitote.2012.04.007

DO - 10.1016/j.fitote.2012.04.007

M3 - 文章

C2 - 22537642

AN - SCOPUS:84861597812

SN - 0367-326X

VL - 83

SP - 926

EP - 931

JO - Fitoterapia

JF - Fitoterapia

IS - 5

ER -

Cycloartane triterpenoids from the stems of Schisandra glaucescens and their bioactivity

Abstract

Keywords

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