Cycloartane triterpenoids from the stems of Schisandra glaucescens and their bioactivity

Juan Zou; Jing Jiang; Yan Yan Diao; Li Bin Yang; Jin Huang; Hong Lin Li; Xue Du; Wei Lie Xiao; Jian Xin Pu; Han Dong Sun

doi:10.1016/j.fitote.2012.04.007

Cycloartane triterpenoids from the stems of Schisandra glaucescens and their bioactivity

Juan Zou, Jing Jiang, Yan Yan Diao, Li Bin Yang, Jin Huang, Hong Lin Li, Xue Du, Wei Lie Xiao^*, Jian Xin Pu, Han Dong Sun

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Five new cycloartane triterpenoids, schiglausins K-O (1-5), including one hexanortriterpenoid (1) and one octanortriterpenoid (2), as well as two known compounds (6-7), were isolated from the stems of Schisandra glaucescens Diels. Their structures were elucidated on the basis of spectroscopic methods, including extensive NMR spectra. Compounds 2-7 were tested for their FXR agonistic and antagonistic effects. Compound 7 exhibited significant antagonistic effect against FXR with IC ₅₀ of 1.50 μM.

Original language	English
Pages (from-to)	926-931
Number of pages	6
Journal	Fitoterapia
Volume	83
Issue number	5
DOIs	https://doi.org/10.1016/j.fitote.2012.04.007
State	Published - Jul 2012
Externally published	Yes

Keywords

Cycloartane triterpenoid
FXR agonistic and antagonistic effects
Schisandra glaucescens
Schisandraceae

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10.1016/j.fitote.2012.04.007

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title = "Cycloartane triterpenoids from the stems of Schisandra glaucescens and their bioactivity",

abstract = "Five new cycloartane triterpenoids, schiglausins K-O (1-5), including one hexanortriterpenoid (1) and one octanortriterpenoid (2), as well as two known compounds (6-7), were isolated from the stems of Schisandra glaucescens Diels. Their structures were elucidated on the basis of spectroscopic methods, including extensive NMR spectra. Compounds 2-7 were tested for their FXR agonistic and antagonistic effects. Compound 7 exhibited significant antagonistic effect against FXR with IC 50 of 1.50 μM.",

keywords = "Cycloartane triterpenoid, FXR agonistic and antagonistic effects, Schisandra glaucescens, Schisandraceae",

author = "Juan Zou and Jing Jiang and Diao, \{Yan Yan\} and Yang, \{Li Bin\} and Jin Huang and Li, \{Hong Lin\} and Xue Du and Xiao, \{Wei Lie\} and Pu, \{Jian Xin\} and Sun, \{Han Dong\}",

year = "2012",

month = jul,

doi = "10.1016/j.fitote.2012.04.007",

language = "英语",

volume = "83",

pages = "926--931",

journal = "Fitoterapia",

issn = "0367-326X",

publisher = "Elsevier B.V.",

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TY - JOUR

T1 - Cycloartane triterpenoids from the stems of Schisandra glaucescens and their bioactivity

AU - Zou, Juan

AU - Jiang, Jing

AU - Diao, Yan Yan

AU - Yang, Li Bin

AU - Huang, Jin

AU - Li, Hong Lin

AU - Du, Xue

AU - Xiao, Wei Lie

AU - Pu, Jian Xin

AU - Sun, Han Dong

PY - 2012/7

Y1 - 2012/7

N2 - Five new cycloartane triterpenoids, schiglausins K-O (1-5), including one hexanortriterpenoid (1) and one octanortriterpenoid (2), as well as two known compounds (6-7), were isolated from the stems of Schisandra glaucescens Diels. Their structures were elucidated on the basis of spectroscopic methods, including extensive NMR spectra. Compounds 2-7 were tested for their FXR agonistic and antagonistic effects. Compound 7 exhibited significant antagonistic effect against FXR with IC 50 of 1.50 μM.

AB - Five new cycloartane triterpenoids, schiglausins K-O (1-5), including one hexanortriterpenoid (1) and one octanortriterpenoid (2), as well as two known compounds (6-7), were isolated from the stems of Schisandra glaucescens Diels. Their structures were elucidated on the basis of spectroscopic methods, including extensive NMR spectra. Compounds 2-7 were tested for their FXR agonistic and antagonistic effects. Compound 7 exhibited significant antagonistic effect against FXR with IC 50 of 1.50 μM.

KW - Cycloartane triterpenoid

KW - FXR agonistic and antagonistic effects

KW - Schisandra glaucescens

KW - Schisandraceae

UR - https://www.scopus.com/pages/publications/84861597812

U2 - 10.1016/j.fitote.2012.04.007

DO - 10.1016/j.fitote.2012.04.007

M3 - 文章

C2 - 22537642

AN - SCOPUS:84861597812

SN - 0367-326X

VL - 83

SP - 926

EP - 931

JO - Fitoterapia

JF - Fitoterapia

IS - 5

ER -

Cycloartane triterpenoids from the stems of Schisandra glaucescens and their bioactivity

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Keywords

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