TY - JOUR
T1 - Curcumin enhances neurogenesis and cognition in aged rats
T2 - Implications for transcriptional interactions related to growth and synaptic plasticity
AU - Dong, Suzhen
AU - Zeng, Qingwen
AU - Mitchell, E. Siobhan
AU - Xiu, Jin
AU - Duan, Yale
AU - Li, Chunxia
AU - Tiwari, Jyoti K.
AU - Hu, Yinghe
AU - Cao, Xiaohua
AU - Zhao, Zheng
PY - 2012/2/16
Y1 - 2012/2/16
N2 - Background: Curcumin has been demonstrated to have many neuroprotective properties, including improvement of cognition in humans and neurogenesis in animals, yet the mechanism of such effects remains unclear. Methodology: We assessed behavioural performance and hippocampal cell proliferation in aged rats after 6- and 12-week curcumin-fortified diets. Curcumin enhanced non-spatial and spatial memory, as well as dentate gyrate cell proliferation as compared to control diet rats. We also investigated underlying mechanistic pathways that might link curcumin treatment to increased cognition and neurogenesis via exon array analysis of cortical and hippocampal mRNA transcription. The results revealed a transcriptional network interaction of genes involved in neurotransmission, neuronal development, signal transduction, and metabolism in response to the curcumin treatment. Conclusions: The results suggest a neurogenesis- and cognition-enhancing potential of prolonged curcumin treatment in aged rats, which may be due to its diverse effects on genes related to growth and plasticity.
AB - Background: Curcumin has been demonstrated to have many neuroprotective properties, including improvement of cognition in humans and neurogenesis in animals, yet the mechanism of such effects remains unclear. Methodology: We assessed behavioural performance and hippocampal cell proliferation in aged rats after 6- and 12-week curcumin-fortified diets. Curcumin enhanced non-spatial and spatial memory, as well as dentate gyrate cell proliferation as compared to control diet rats. We also investigated underlying mechanistic pathways that might link curcumin treatment to increased cognition and neurogenesis via exon array analysis of cortical and hippocampal mRNA transcription. The results revealed a transcriptional network interaction of genes involved in neurotransmission, neuronal development, signal transduction, and metabolism in response to the curcumin treatment. Conclusions: The results suggest a neurogenesis- and cognition-enhancing potential of prolonged curcumin treatment in aged rats, which may be due to its diverse effects on genes related to growth and plasticity.
UR - https://www.scopus.com/pages/publications/84863149995
U2 - 10.1371/journal.pone.0031211
DO - 10.1371/journal.pone.0031211
M3 - 文章
C2 - 22359574
AN - SCOPUS:84863149995
SN - 1932-6203
VL - 7
JO - PLoS ONE
JF - PLoS ONE
IS - 2
M1 - e31211
ER -