Cu-mediated selective O-arylation on C-6 substituted pyridin-2-ones

Taijie Chen; Qingqing Huang; Yu Luo; Youhong Hu; Wei Lu

doi:10.1016/j.tetlet.2012.12.126

Cu-mediated selective O-arylation on C-6 substituted pyridin-2-ones

Taijie Chen
, Qingqing Huang
, Yu Luo^*
, Youhong Hu
, Wei Lu

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

A practical and mild strategy has been developed for the selective O-arylation on C-6 substituted pyridin- 2-ones with a series of arylboronic acids, using Cu(OTf)₂ as the catalyst, DABCO as the ligand, Et3N as the base, and K₂HPO₄ as the additive. This method affords O-arylated pyridin-2-ones with good selectivity and yields.

Original language	English
Pages (from-to)	1401-1404
Number of pages	4
Journal	Tetrahedron Letters
Volume	54
Issue number	11
DOIs	https://doi.org/10.1016/j.tetlet.2012.12.126
State	Published - 13 Mar 2013

Keywords

Arylboronic acids
Chan-Evans-Lam cross-coupling
O-arylation
Pyridin-2-ones
Selectivity

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10.1016/j.tetlet.2012.12.126

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title = "Cu-mediated selective O-arylation on C-6 substituted pyridin-2-ones",

abstract = "A practical and mild strategy has been developed for the selective O-arylation on C-6 substituted pyridin- 2-ones with a series of arylboronic acids, using Cu(OTf)2 as the catalyst, DABCO as the ligand, Et3N as the base, and K2HPO4 as the additive. This method affords O-arylated pyridin-2-ones with good selectivity and yields.",

keywords = "Arylboronic acids, Chan-Evans-Lam cross-coupling, O-arylation, Pyridin-2-ones, Selectivity",

author = "Taijie Chen and Qingqing Huang and Yu Luo and Youhong Hu and Wei Lu",

year = "2013",

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language = "英语",

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T1 - Cu-mediated selective O-arylation on C-6 substituted pyridin-2-ones

AU - Chen, Taijie

AU - Huang, Qingqing

AU - Luo, Yu

AU - Hu, Youhong

AU - Lu, Wei

PY - 2013/3/13

Y1 - 2013/3/13

N2 - A practical and mild strategy has been developed for the selective O-arylation on C-6 substituted pyridin- 2-ones with a series of arylboronic acids, using Cu(OTf)2 as the catalyst, DABCO as the ligand, Et3N as the base, and K2HPO4 as the additive. This method affords O-arylated pyridin-2-ones with good selectivity and yields.

AB - A practical and mild strategy has been developed for the selective O-arylation on C-6 substituted pyridin- 2-ones with a series of arylboronic acids, using Cu(OTf)2 as the catalyst, DABCO as the ligand, Et3N as the base, and K2HPO4 as the additive. This method affords O-arylated pyridin-2-ones with good selectivity and yields.

KW - Arylboronic acids

KW - Chan-Evans-Lam cross-coupling

KW - O-arylation

KW - Pyridin-2-ones

KW - Selectivity

UR - https://www.scopus.com/pages/publications/84874943044

U2 - 10.1016/j.tetlet.2012.12.126

DO - 10.1016/j.tetlet.2012.12.126

M3 - 文章

AN - SCOPUS:84874943044

SN - 0040-4039

VL - 54

SP - 1401

EP - 1404

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 11

ER -

Cu-mediated selective O-arylation on C-6 substituted pyridin-2-ones

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Keywords

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