Abstract
With substituted salicylaldehyde as racemization catalyst, crystallization-induced dynamic kinetic resolution of phenylglycine amide was successfully carried out in the presence of resolving agent. Under optimized conditions, the single-run resolution yield was upward 82% with enantiomeric excess higher than 99%. The resolving agent can be recycled, and the mother liquid which contains the racemization catalyst can be reused. The average yield of the three time's recycling was up to 99% with ee>99%.
| Original language | English |
|---|---|
| Pages (from-to) | 1495-1498 |
| Number of pages | 4 |
| Journal | Chinese Journal of Organic Chemistry |
| Volume | 31 |
| Issue number | 9 |
| State | Published - Sep 2011 |
Keywords
- 5-nitrosalicylaldehyde
- Dynamic kinetic resolution
- Mandelic acid
- Phenylglycine amide