Crystallization-induced dynamic kinetic resolution of phenylglycine amide

Benren Liao; Guocheng An; Junru Zhu; Fan Yang; Jie Tang

Crystallization-induced dynamic kinetic resolution of phenylglycine amide

Benren Liao
, Guocheng An
, Junru Zhu
, Fan Yang^*
, Jie Tang

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

East China Normal University
Shanghai Huayi Group Technology Research Institute

Research output: Contribution to journal › Article › peer-review

Abstract

With substituted salicylaldehyde as racemization catalyst, crystallization-induced dynamic kinetic resolution of phenylglycine amide was successfully carried out in the presence of resolving agent. Under optimized conditions, the single-run resolution yield was upward 82% with enantiomeric excess higher than 99%. The resolving agent can be recycled, and the mother liquid which contains the racemization catalyst can be reused. The average yield of the three time's recycling was up to 99% with ee>99%.

Original language	English
Pages (from-to)	1495-1498
Number of pages	4
Journal	Chinese Journal of Organic Chemistry
Volume	31
Issue number	9
State	Published - Sep 2011

Keywords

5-nitrosalicylaldehyde
Dynamic kinetic resolution
Mandelic acid
Phenylglycine amide

Cite this

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title = "Crystallization-induced dynamic kinetic resolution of phenylglycine amide",

abstract = "With substituted salicylaldehyde as racemization catalyst, crystallization-induced dynamic kinetic resolution of phenylglycine amide was successfully carried out in the presence of resolving agent. Under optimized conditions, the single-run resolution yield was upward 82\% with enantiomeric excess higher than 99\%. The resolving agent can be recycled, and the mother liquid which contains the racemization catalyst can be reused. The average yield of the three time's recycling was up to 99\% with ee>99\%.",

keywords = "5-nitrosalicylaldehyde, Dynamic kinetic resolution, Mandelic acid, Phenylglycine amide",

author = "Benren Liao and Guocheng An and Junru Zhu and Fan Yang and Jie Tang",

year = "2011",

month = sep,

language = "英语",

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journal = "Chinese Journal of Organic Chemistry",

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TY - JOUR

T1 - Crystallization-induced dynamic kinetic resolution of phenylglycine amide

AU - Liao, Benren

AU - An, Guocheng

AU - Zhu, Junru

AU - Yang, Fan

AU - Tang, Jie

PY - 2011/9

Y1 - 2011/9

N2 - With substituted salicylaldehyde as racemization catalyst, crystallization-induced dynamic kinetic resolution of phenylglycine amide was successfully carried out in the presence of resolving agent. Under optimized conditions, the single-run resolution yield was upward 82% with enantiomeric excess higher than 99%. The resolving agent can be recycled, and the mother liquid which contains the racemization catalyst can be reused. The average yield of the three time's recycling was up to 99% with ee>99%.

AB - With substituted salicylaldehyde as racemization catalyst, crystallization-induced dynamic kinetic resolution of phenylglycine amide was successfully carried out in the presence of resolving agent. Under optimized conditions, the single-run resolution yield was upward 82% with enantiomeric excess higher than 99%. The resolving agent can be recycled, and the mother liquid which contains the racemization catalyst can be reused. The average yield of the three time's recycling was up to 99% with ee>99%.

KW - 5-nitrosalicylaldehyde

KW - Dynamic kinetic resolution

KW - Mandelic acid

KW - Phenylglycine amide

UR - https://www.scopus.com/pages/publications/83655196779

M3 - 文章

AN - SCOPUS:83655196779

SN - 0253-2786

VL - 31

SP - 1495

EP - 1498

JO - Chinese Journal of Organic Chemistry

JF - Chinese Journal of Organic Chemistry

IS - 9

ER -

Crystallization-induced dynamic kinetic resolution of phenylglycine amide

Abstract

Keywords

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