Crucial role for phylogenetically conserved cytoplasmic loop 3 in ABCC4 protein expression

Satish B. Cheepala; Ju Bao; Deepa Nachagari; Daxi Sun; Yao Wang; Tao Zhong; Anjaparavanda P. Naren; Jie Zheng; John D. Schuetz

doi:10.1074/jbc.M113.476218

Crucial role for phylogenetically conserved cytoplasmic loop 3 in ABCC4 protein expression

Satish B. Cheepala
, Ju Bao
, Deepa Nachagari
, Daxi Sun
, Yao Wang
, Tao Zhong
, Anjaparavanda P. Naren
, Jie Zheng
, John D. Schuetz^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Background: The role of cytoplasmic loops (CL) in ABCC4 expression at the plasma membrane is unknown. Results: A conserved amino acid substitution in the CL3 of ABCC4 reduced expression and impaired membrane localization. Conclusion: An α-helical domain in CL3 appears crucial for proper ABCC4 plasma membrane localization. Significance: These findings reveal ABCC4 membrane localization requires a conserved domain in CL3.

Original language	English
Pages (from-to)	22207-22218
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	288
Issue number	31
DOIs	https://doi.org/10.1074/jbc.M113.476218
State	Published - 2 Aug 2013
Externally published	Yes

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title = "Crucial role for phylogenetically conserved cytoplasmic loop 3 in ABCC4 protein expression",

abstract = "Background: The role of cytoplasmic loops (CL) in ABCC4 expression at the plasma membrane is unknown. Results: A conserved amino acid substitution in the CL3 of ABCC4 reduced expression and impaired membrane localization. Conclusion: An α-helical domain in CL3 appears crucial for proper ABCC4 plasma membrane localization. Significance: These findings reveal ABCC4 membrane localization requires a conserved domain in CL3.",

author = "Cheepala, \{Satish B.\} and Ju Bao and Deepa Nachagari and Daxi Sun and Yao Wang and Tao Zhong and Naren, \{Anjaparavanda P.\} and Jie Zheng and Schuetz, \{John D.\}",

year = "2013",

month = aug,

day = "2",

doi = "10.1074/jbc.M113.476218",

language = "英语",

volume = "288",

pages = "22207--22218",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

publisher = "American Society for Biochemistry and Molecular Biology Inc.",

number = "31",

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TY - JOUR

T1 - Crucial role for phylogenetically conserved cytoplasmic loop 3 in ABCC4 protein expression

AU - Cheepala, Satish B.

AU - Bao, Ju

AU - Nachagari, Deepa

AU - Sun, Daxi

AU - Wang, Yao

AU - Zhong, Tao

AU - Naren, Anjaparavanda P.

AU - Zheng, Jie

AU - Schuetz, John D.

PY - 2013/8/2

Y1 - 2013/8/2

N2 - Background: The role of cytoplasmic loops (CL) in ABCC4 expression at the plasma membrane is unknown. Results: A conserved amino acid substitution in the CL3 of ABCC4 reduced expression and impaired membrane localization. Conclusion: An α-helical domain in CL3 appears crucial for proper ABCC4 plasma membrane localization. Significance: These findings reveal ABCC4 membrane localization requires a conserved domain in CL3.

AB - Background: The role of cytoplasmic loops (CL) in ABCC4 expression at the plasma membrane is unknown. Results: A conserved amino acid substitution in the CL3 of ABCC4 reduced expression and impaired membrane localization. Conclusion: An α-helical domain in CL3 appears crucial for proper ABCC4 plasma membrane localization. Significance: These findings reveal ABCC4 membrane localization requires a conserved domain in CL3.

UR - https://www.scopus.com/pages/publications/84881225182

U2 - 10.1074/jbc.M113.476218

DO - 10.1074/jbc.M113.476218

M3 - 文章

C2 - 23766510

AN - SCOPUS:84881225182

SN - 0021-9258

VL - 288

SP - 22207

EP - 22218

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 31

ER -

Crucial role for phylogenetically conserved cytoplasmic loop 3 in ABCC4 protein expression

Abstract

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