Core–Shell-structured Dendritic Mesoporous Silica Nanoparticles for Combined Photodynamic Therapy and Antibody Delivery

  • Prasanna Lakshmi Abbaraju
  • , Yannan Yang
  • , Meihua Yu
  • , Jianye Fu
  • , Chun Xu
  • , Chengzhong Yu*
  • *Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Multifunctional core–shell-structured dendritic mesoporous silica nanoparticles with a fullerene-doped silica core, a dendritic silica shell and large pores have been prepared. The combination of photodynamic therapy and antibody therapeutics significantly inhibits the cancer cell growth by effectively reducing the level of anti-apoptotic proteins.

Original languageEnglish
Pages (from-to)1465-1469
Number of pages5
JournalChemistry - An Asian Journal
Volume12
Issue number13
DOIs
StatePublished - 4 Jul 2017
Externally publishedYes

Keywords

  • anti-apoptotic proteins
  • antibody therapeutics
  • fullerenes
  • mesoporous silica nanoparticles
  • photodynamic therapy

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