Core-Cone Structured Monodispersed Mesoporous Silica Nanoparticles with Ultra-large Cavity for Protein Delivery

Chun Xu; Meihua Yu; Owen Noonan; Jun Zhang; Hao Song; Hongwei Zhang; Chang Lei; Yuting Niu; Xiaodan Huang; Yannan Yang; Chengzhong Yu

doi:10.1002/smll.201501449

Core-Cone Structured Monodispersed Mesoporous Silica Nanoparticles with Ultra-large Cavity for Protein Delivery

Chun Xu
, Meihua Yu
, Owen Noonan
, Jun Zhang
, Hao Song
, Hongwei Zhang
, Chang Lei
, Yuting Niu
, Xiaodan Huang
, Yannan Yang
, Chengzhong Yu^*

^*Corresponding author for this work

University of Queensland

Research output: Contribution to journal › Article › peer-review

164 Scopus citations

Abstract

A new type of monodispersed mesoporous silica nanoparticles with a core-cone structure (MSN-CC) has been synthesized. The large cone-shaped pores are formed by silica lamellae closely packed encircling a spherical core, showing a structure similar to the flower dahlia. MSN-CC has a large pore size of 45 nm and a high pore volume of 2.59 cm³ g^-1. MSN-CC demonstrates a high loading capacity of large proteins and successfully delivers active β-galactosidase into cells, showing their potential as efficient nanocarriers for the cellular delivery of proteins with large molecular weights. Dahlia-like silica: A new type of monodispersed mesoporous silica nanoparticle with core-cone structures (MSN-CC) is synthesized. The cone-shaped large pores are formed by silica lamellae closely packed encircling a spherical core, showing a structure similar to a dahlia. MSN-CC demonstrates successful intracellular delivery of large protein of β-galactosidase (β-gal, 119 kDa) and retains its protein enzymatic activity.

Original language	English
Pages (from-to)	5949-5955
Number of pages	7
Journal	Small
Volume	11
Issue number	44
DOIs	https://doi.org/10.1002/smll.201501449
State	Published - 25 Nov 2015
Externally published	Yes

Keywords

large pores
mesoporous silica
nanoparticles
protein delivery

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10.1002/smll.201501449

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@article{8806c13856b34ca58de105f1f65f7331,

title = "Core-Cone Structured Monodispersed Mesoporous Silica Nanoparticles with Ultra-large Cavity for Protein Delivery",

abstract = "A new type of monodispersed mesoporous silica nanoparticles with a core-cone structure (MSN-CC) has been synthesized. The large cone-shaped pores are formed by silica lamellae closely packed encircling a spherical core, showing a structure similar to the flower dahlia. MSN-CC has a large pore size of 45 nm and a high pore volume of 2.59 cm3 g-1. MSN-CC demonstrates a high loading capacity of large proteins and successfully delivers active β-galactosidase into cells, showing their potential as efficient nanocarriers for the cellular delivery of proteins with large molecular weights. Dahlia-like silica: A new type of monodispersed mesoporous silica nanoparticle with core-cone structures (MSN-CC) is synthesized. The cone-shaped large pores are formed by silica lamellae closely packed encircling a spherical core, showing a structure similar to a dahlia. MSN-CC demonstrates successful intracellular delivery of large protein of β-galactosidase (β-gal, 119 kDa) and retains its protein enzymatic activity.",

keywords = "large pores, mesoporous silica, nanoparticles, protein delivery",

author = "Chun Xu and Meihua Yu and Owen Noonan and Jun Zhang and Hao Song and Hongwei Zhang and Chang Lei and Yuting Niu and Xiaodan Huang and Yannan Yang and Chengzhong Yu",

note = "Publisher Copyright: {\textcopyright} 2015 WILEY-VCH Verlag GmbH \& Co. KGaA, Weinheim.",

year = "2015",

month = nov,

day = "25",

doi = "10.1002/smll.201501449",

language = "英语",

volume = "11",

pages = "5949--5955",

journal = "Small",

issn = "1613-6810",

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T1 - Core-Cone Structured Monodispersed Mesoporous Silica Nanoparticles with Ultra-large Cavity for Protein Delivery

AU - Xu, Chun

AU - Yu, Meihua

AU - Noonan, Owen

AU - Zhang, Jun

AU - Song, Hao

AU - Zhang, Hongwei

AU - Lei, Chang

AU - Niu, Yuting

AU - Huang, Xiaodan

AU - Yang, Yannan

AU - Yu, Chengzhong

PY - 2015/11/25

Y1 - 2015/11/25

N2 - A new type of monodispersed mesoporous silica nanoparticles with a core-cone structure (MSN-CC) has been synthesized. The large cone-shaped pores are formed by silica lamellae closely packed encircling a spherical core, showing a structure similar to the flower dahlia. MSN-CC has a large pore size of 45 nm and a high pore volume of 2.59 cm3 g-1. MSN-CC demonstrates a high loading capacity of large proteins and successfully delivers active β-galactosidase into cells, showing their potential as efficient nanocarriers for the cellular delivery of proteins with large molecular weights. Dahlia-like silica: A new type of monodispersed mesoporous silica nanoparticle with core-cone structures (MSN-CC) is synthesized. The cone-shaped large pores are formed by silica lamellae closely packed encircling a spherical core, showing a structure similar to a dahlia. MSN-CC demonstrates successful intracellular delivery of large protein of β-galactosidase (β-gal, 119 kDa) and retains its protein enzymatic activity.

AB - A new type of monodispersed mesoporous silica nanoparticles with a core-cone structure (MSN-CC) has been synthesized. The large cone-shaped pores are formed by silica lamellae closely packed encircling a spherical core, showing a structure similar to the flower dahlia. MSN-CC has a large pore size of 45 nm and a high pore volume of 2.59 cm3 g-1. MSN-CC demonstrates a high loading capacity of large proteins and successfully delivers active β-galactosidase into cells, showing their potential as efficient nanocarriers for the cellular delivery of proteins with large molecular weights. Dahlia-like silica: A new type of monodispersed mesoporous silica nanoparticle with core-cone structures (MSN-CC) is synthesized. The cone-shaped large pores are formed by silica lamellae closely packed encircling a spherical core, showing a structure similar to a dahlia. MSN-CC demonstrates successful intracellular delivery of large protein of β-galactosidase (β-gal, 119 kDa) and retains its protein enzymatic activity.

KW - large pores

KW - mesoporous silica

KW - nanoparticles

KW - protein delivery

UR - https://www.scopus.com/pages/publications/84955202063

U2 - 10.1002/smll.201501449

DO - 10.1002/smll.201501449

M3 - 文章

C2 - 26426420

AN - SCOPUS:84955202063

SN - 1613-6810

VL - 11

SP - 5949

EP - 5955

JO - Small

JF - Small

IS - 44

ER -

Core-Cone Structured Monodispersed Mesoporous Silica Nanoparticles with Ultra-large Cavity for Protein Delivery

Abstract

Keywords

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