Copper(I)/SaBOX catalyzed highly diastereo- and enantio-selective cyclopropanation of cis-1,2-disubstituted olefins with α-nitrodiazoacetates

Liang Wen Feng; Peng Wang; Lijia Wang; Yong Tang

doi:10.1007/s11434-014-0708-5

Copper(I)/SaBOX catalyzed highly diastereo- and enantio-selective cyclopropanation of cis-1,2-disubstituted olefins with α-nitrodiazoacetates

Liang Wen Feng
, Peng Wang
, Lijia Wang
, Yong Tang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

A copper-catalyzed highly stereoselective cyclopropanation of 1,2-disubstituted olefins with α-nitrodiazo acetates has been developed, giving the desired products in up to 97 % yields, up to >99/1 dr and up to 98 % ee, which provides an efficient access to the synthesis of optical active cyclopropane α-amino acids and unnatural α-amino acid derivatives.

Original language	English
Pages (from-to)	210-215
Number of pages	6
Journal	Science Bulletin
Volume	60
Issue number	2
DOIs	https://doi.org/10.1007/s11434-014-0708-5
State	Published - 9 Jan 2015
Externally published	Yes

Keywords

Asymmetric catalysis
Bisoxazoline
Cyclopropanation
Sidearm
α-Amino acids

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@article{f8c3335805e2487c8647988e0f94dc90,

title = "Copper(I)/SaBOX catalyzed highly diastereo- and enantio-selective cyclopropanation of cis-1,2-disubstituted olefins with α-nitrodiazoacetates",

abstract = "A copper-catalyzed highly stereoselective cyclopropanation of 1,2-disubstituted olefins with α-nitrodiazo acetates has been developed, giving the desired products in up to 97 \% yields, up to >99/1 dr and up to 98 \% ee, which provides an efficient access to the synthesis of optical active cyclopropane α-amino acids and unnatural α-amino acid derivatives.",

keywords = "Asymmetric catalysis, Bisoxazoline, Cyclopropanation, Sidearm, α-Amino acids",

author = "Feng, \{Liang Wen\} and Peng Wang and Lijia Wang and Yong Tang",

note = "Publisher Copyright: {\textcopyright} 2014, Science China Press and Springer-Verlag Berlin Heidelberg.",

year = "2015",

month = jan,

day = "9",

doi = "10.1007/s11434-014-0708-5",

language = "英语",

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pages = "210--215",

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T1 - Copper(I)/SaBOX catalyzed highly diastereo- and enantio-selective cyclopropanation of cis-1,2-disubstituted olefins with α-nitrodiazoacetates

AU - Feng, Liang Wen

AU - Wang, Peng

AU - Wang, Lijia

AU - Tang, Yong

PY - 2015/1/9

Y1 - 2015/1/9

N2 - A copper-catalyzed highly stereoselective cyclopropanation of 1,2-disubstituted olefins with α-nitrodiazo acetates has been developed, giving the desired products in up to 97 % yields, up to >99/1 dr and up to 98 % ee, which provides an efficient access to the synthesis of optical active cyclopropane α-amino acids and unnatural α-amino acid derivatives.

AB - A copper-catalyzed highly stereoselective cyclopropanation of 1,2-disubstituted olefins with α-nitrodiazo acetates has been developed, giving the desired products in up to 97 % yields, up to >99/1 dr and up to 98 % ee, which provides an efficient access to the synthesis of optical active cyclopropane α-amino acids and unnatural α-amino acid derivatives.

KW - Asymmetric catalysis

KW - Bisoxazoline

KW - Cyclopropanation

KW - Sidearm

KW - α-Amino acids

UR - https://www.scopus.com/pages/publications/84930948047

U2 - 10.1007/s11434-014-0708-5

DO - 10.1007/s11434-014-0708-5

M3 - 文章

AN - SCOPUS:84930948047

SN - 2095-9273

VL - 60

SP - 210

EP - 215

JO - Science Bulletin

JF - Science Bulletin

IS - 2

ER -

Copper(I)/SaBOX catalyzed highly diastereo- and enantio-selective cyclopropanation of cis-1,2-disubstituted olefins with α-nitrodiazoacetates

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Keywords

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