Copper-catalyzed chemoselective C-H functionalization/dearomatization sequence: direct access to indole-based spirocyclic scaffolds

Yuting Zhao; Xin Ji; Yuanjing Xiao; Xingxing Wu; Lu Liu

doi:10.1039/d5cc00594a

Copper-catalyzed chemoselective C-H functionalization/dearomatization sequence: direct access to indole-based spirocyclic scaffolds

Yuting Zhao
, Xin Ji
, Yuanjing Xiao^*
, Xingxing Wu^*
, Lu Liu^*

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

East China Normal University
Guizhou University
Shihezi University

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Herein, a copper-catalyzed intermolecular [4+1] spiroannulation of indoles with alkynyldiazoketones affording various indole-based spirocyclic molecules via a chemoselective C-H functionalization/dearomatization sequence was developed.

Original language	English
Pages (from-to)	5162-5165
Number of pages	4
Journal	Chemical Communications
Volume	61
Issue number	27
DOIs	https://doi.org/10.1039/d5cc00594a
State	Published - 5 Mar 2025

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10.1039/d5cc00594a

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title = "Copper-catalyzed chemoselective C-H functionalization/dearomatization sequence: direct access to indole-based spirocyclic scaffolds",

abstract = "Herein, a copper-catalyzed intermolecular [4+1] spiroannulation of indoles with alkynyldiazoketones affording various indole-based spirocyclic molecules via a chemoselective C-H functionalization/dearomatization sequence was developed.",

author = "Yuting Zhao and Xin Ji and Yuanjing Xiao and Xingxing Wu and Lu Liu",

note = "Publisher Copyright: {\textcopyright} 2025 The Royal Society of Chemistry.",

year = "2025",

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doi = "10.1039/d5cc00594a",

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volume = "61",

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journal = "Chemical Communications",

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TY - JOUR

T1 - Copper-catalyzed chemoselective C-H functionalization/dearomatization sequence

T2 - direct access to indole-based spirocyclic scaffolds

AU - Zhao, Yuting

AU - Ji, Xin

AU - Xiao, Yuanjing

AU - Wu, Xingxing

AU - Liu, Lu

PY - 2025/3/5

Y1 - 2025/3/5

N2 - Herein, a copper-catalyzed intermolecular [4+1] spiroannulation of indoles with alkynyldiazoketones affording various indole-based spirocyclic molecules via a chemoselective C-H functionalization/dearomatization sequence was developed.

AB - Herein, a copper-catalyzed intermolecular [4+1] spiroannulation of indoles with alkynyldiazoketones affording various indole-based spirocyclic molecules via a chemoselective C-H functionalization/dearomatization sequence was developed.

UR - https://www.scopus.com/pages/publications/86000600514

U2 - 10.1039/d5cc00594a

DO - 10.1039/d5cc00594a

M3 - 文章

C2 - 40070230

AN - SCOPUS:86000600514

SN - 1359-7345

VL - 61

SP - 5162

EP - 5165

JO - Chemical Communications

JF - Chemical Communications

IS - 27

ER -

Copper-catalyzed chemoselective C-H functionalization/dearomatization sequence: direct access to indole-based spirocyclic scaffolds

Abstract

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