Coordination-drIVen self-assembly of a Pt(IV) prodrug-conjugated supramolecular hexagon

Zhizhou Yue; Han Wang; Yiming Li; Yi Qin; Lin Xu; David J. Bowers; Mahinda Gangoda; Xiaopeng Li; Hai Bo Yang; Yao Rong Zheng

doi:10.1039/c7cc07622c

Coordination-drIVen self-assembly of a Pt(IV) prodrug-conjugated supramolecular hexagon

Zhizhou Yue
, Han Wang
, Yiming Li
, Yi Qin
, Lin Xu
, David J. Bowers
, Mahinda Gangoda
, Xiaopeng Li
, Hai Bo Yang
, Yao Rong Zheng^*

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

This article presents a new strategy to engage coordination-driven self-assembly for platinum drug delivery. The self-assembled supramolecular hexagon is conjugated with three equivalents of Pt(iv) prodrugs and displays a superior therapeutic index compared to cisplatin against a panel of human cancer cell lines.

Original language	English
Pages (from-to)	731-734
Number of pages	4
Journal	Chemical Communications
Volume	54
Issue number	7
DOIs	https://doi.org/10.1039/c7cc07622c
State	Published - 2018

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10.1039/c7cc07622c

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title = "Coordination-drIVen self-assembly of a Pt(IV) prodrug-conjugated supramolecular hexagon",

abstract = "This article presents a new strategy to engage coordination-driven self-assembly for platinum drug delivery. The self-assembled supramolecular hexagon is conjugated with three equivalents of Pt(iv) prodrugs and displays a superior therapeutic index compared to cisplatin against a panel of human cancer cell lines.",

author = "Zhizhou Yue and Han Wang and Yiming Li and Yi Qin and Lin Xu and Bowers, \{David J.\} and Mahinda Gangoda and Xiaopeng Li and Yang, \{Hai Bo\} and Zheng, \{Yao Rong\}",

note = "Publisher Copyright: {\textcopyright} 2018 The Royal Society of Chemistry.",

year = "2018",

doi = "10.1039/c7cc07622c",

language = "英语",

volume = "54",

pages = "731--734",

journal = "Chemical Communications",

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publisher = "Royal Society of Chemistry",

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T1 - Coordination-drIVen self-assembly of a Pt(IV) prodrug-conjugated supramolecular hexagon

AU - Yue, Zhizhou

AU - Wang, Han

AU - Li, Yiming

AU - Qin, Yi

AU - Xu, Lin

AU - Bowers, David J.

AU - Gangoda, Mahinda

AU - Li, Xiaopeng

AU - Yang, Hai Bo

AU - Zheng, Yao Rong

PY - 2018

Y1 - 2018

N2 - This article presents a new strategy to engage coordination-driven self-assembly for platinum drug delivery. The self-assembled supramolecular hexagon is conjugated with three equivalents of Pt(iv) prodrugs and displays a superior therapeutic index compared to cisplatin against a panel of human cancer cell lines.

AB - This article presents a new strategy to engage coordination-driven self-assembly for platinum drug delivery. The self-assembled supramolecular hexagon is conjugated with three equivalents of Pt(iv) prodrugs and displays a superior therapeutic index compared to cisplatin against a panel of human cancer cell lines.

UR - https://www.scopus.com/pages/publications/85040983607

U2 - 10.1039/c7cc07622c

DO - 10.1039/c7cc07622c

M3 - 文章

C2 - 29303526

AN - SCOPUS:85040983607

SN - 1359-7345

VL - 54

SP - 731

EP - 734

JO - Chemical Communications

JF - Chemical Communications

IS - 7

ER -

Coordination-drIVen self-assembly of a Pt(IV) prodrug-conjugated supramolecular hexagon

Abstract

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