Convenient synthesis of sorafenib and its derivatives

Lijuan Zhang; Wenpin Xia; Bo Wang; Yu Luo; Wei Lu

doi:10.1080/00397911.2010.517372

Convenient synthesis of sorafenib and its derivatives

Lijuan Zhang, Wenpin Xia, Bo Wang, Yu Luo, Wei Lu

School of Chemistry and Molecular Engineering

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

This article describes a convenient synthesis of sorafinib and its derivatives from phenyl carbamates in good yields. This procedure, avoiding toxic phosgene, is especially suitable for large-scale preparation.

Original language	English
Pages (from-to)	3140-3146
Number of pages	7
Journal	Synthetic Communications
Volume	41
Issue number	21
DOIs	https://doi.org/10.1080/00397911.2010.517372
State	Published - Jan 2011

Keywords

Aminolysis
phenyl carbamate
sorafenib
unsymmetrical urea

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10.1080/00397911.2010.517372

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title = "Convenient synthesis of sorafenib and its derivatives",

abstract = "This article describes a convenient synthesis of sorafinib and its derivatives from phenyl carbamates in good yields. This procedure, avoiding toxic phosgene, is especially suitable for large-scale preparation.",

keywords = "Aminolysis, phenyl carbamate, sorafenib, unsymmetrical urea",

author = "Lijuan Zhang and Wenpin Xia and Bo Wang and Yu Luo and Wei Lu",

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T1 - Convenient synthesis of sorafenib and its derivatives

AU - Zhang, Lijuan

AU - Xia, Wenpin

AU - Wang, Bo

AU - Luo, Yu

AU - Lu, Wei

PY - 2011/1

Y1 - 2011/1

N2 - This article describes a convenient synthesis of sorafinib and its derivatives from phenyl carbamates in good yields. This procedure, avoiding toxic phosgene, is especially suitable for large-scale preparation.

AB - This article describes a convenient synthesis of sorafinib and its derivatives from phenyl carbamates in good yields. This procedure, avoiding toxic phosgene, is especially suitable for large-scale preparation.

KW - Aminolysis

KW - phenyl carbamate

KW - sorafenib

KW - unsymmetrical urea

UR - https://www.scopus.com/pages/publications/79960630626

U2 - 10.1080/00397911.2010.517372

DO - 10.1080/00397911.2010.517372

M3 - 文章

AN - SCOPUS:79960630626

SN - 0039-7911

VL - 41

SP - 3140

EP - 3146

JO - Synthetic Communications

JF - Synthetic Communications

IS - 21

ER -

Convenient synthesis of sorafenib and its derivatives

Abstract

Keywords

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