Abstract
Ophiobolin and variecolin type sesterterpenoids belong to cyclooctane-containing natural products. Both sesterterpenoids have challenging structures and appealing biological activities. We envisioned that a key tandem ring closing metathesis of dienynes could provide the basic skeleton of ophiobolin A and variecolin. We report herein the detailed reactivities of the dienynes which furnished the 5-8-5 and 5-8-6-5 rings efficiently.
| Original language | English |
|---|---|
| Pages (from-to) | 7550-7558 |
| Number of pages | 9 |
| Journal | Organic and Biomolecular Chemistry |
| Volume | 11 |
| Issue number | 43 |
| DOIs | |
| State | Published - 21 Nov 2013 |