Construction of spirotetrahydroquinolines fused with medium-sized rings via TBHP/base-promoted spirocyclization reactions

Peng He; Yuanyang Mu; Zongkang Wang; Nana Fei; Chengyu Wang; Yanzhong Li

doi:10.1039/d5qo00648a

Construction of spirotetrahydroquinolines fused with medium-sized rings via TBHP/base-promoted spirocyclization reactions

Peng He
, Yuanyang Mu
, Zongkang Wang
, Nana Fei
, Chengyu Wang^*
, Yanzhong Li^*

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

An efficient and straightforward methodology for synthesising spirotetrahydroquinolines fused with medium-sized rings (including 7, 8, and 9-membered rings) by TBHP/base-promoted spirocyclization reactions has been developed. The present report provides a transition-metal-free method with a wide range of substitution patterns, functional group compatibility and good diastereoselectivity.

Original language	English
Pages (from-to)	5346-5350
Number of pages	5
Journal	Organic Chemistry Frontiers
Volume	12
Issue number	19
DOIs	https://doi.org/10.1039/d5qo00648a
State	Published - 23 Sep 2025

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title = "Construction of spirotetrahydroquinolines fused with medium-sized rings via TBHP/base-promoted spirocyclization reactions",

abstract = "An efficient and straightforward methodology for synthesising spirotetrahydroquinolines fused with medium-sized rings (including 7, 8, and 9-membered rings) by TBHP/base-promoted spirocyclization reactions has been developed. The present report provides a transition-metal-free method with a wide range of substitution patterns, functional group compatibility and good diastereoselectivity.",

author = "Peng He and Yuanyang Mu and Zongkang Wang and Nana Fei and Chengyu Wang and Yanzhong Li",

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AU - He, Peng

AU - Mu, Yuanyang

AU - Wang, Zongkang

AU - Fei, Nana

AU - Wang, Chengyu

AU - Li, Yanzhong

PY - 2025/9/23

Y1 - 2025/9/23

N2 - An efficient and straightforward methodology for synthesising spirotetrahydroquinolines fused with medium-sized rings (including 7, 8, and 9-membered rings) by TBHP/base-promoted spirocyclization reactions has been developed. The present report provides a transition-metal-free method with a wide range of substitution patterns, functional group compatibility and good diastereoselectivity.

AB - An efficient and straightforward methodology for synthesising spirotetrahydroquinolines fused with medium-sized rings (including 7, 8, and 9-membered rings) by TBHP/base-promoted spirocyclization reactions has been developed. The present report provides a transition-metal-free method with a wide range of substitution patterns, functional group compatibility and good diastereoselectivity.

UR - https://www.scopus.com/pages/publications/105007608622

U2 - 10.1039/d5qo00648a

DO - 10.1039/d5qo00648a

M3 - 文章

AN - SCOPUS:105007608622

SN - 2052-4110

VL - 12

SP - 5346

EP - 5350

JO - Organic Chemistry Frontiers

JF - Organic Chemistry Frontiers

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ER -

Construction of spirotetrahydroquinolines fused with medium-sized rings via TBHP/base-promoted spirocyclization reactions

Abstract

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