Concluding Remarks

Jie Xu; Mingyao Liu

doi:10.1007/978-981-15-3266-5_24

Concluding Remarks

Jie Xu^*
, Mingyao Liu

^*Corresponding author for this work

School of Life Sciences

Fudan University

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

The regulation of immune checkpoint is a pivotal mechanism mediating both self-tolerance physiologically and tumor immune evasion pathologically. Along with an increasing number of identified checkpoint ligand–receptor pairs, the complexity of regulation at genetic, epigenetic, transcriptional, translational, and post-translational levels makes it highly challenging to assemble a comprehensive regulatory network. Advanced animal models are required for determining the exact regulatory effects, given the differences in human and mouse immune systems. Our further understanding on checkpoint regulation may energize translational studies aimed to improve cancer immunotherapy, and collaborations between researchers with different expertise would help to tackle existing challenges in this field.

Original language	English
Title of host publication	Advances in Experimental Medicine and Biology
Publisher	Springer
Pages	651-653
Number of pages	3
DOIs	https://doi.org/10.1007/978-981-15-3266-5_24
State	Published - 2020

Publication series

Name	Advances in Experimental Medicine and Biology
Volume	1248
ISSN (Print)	0065-2598
ISSN (Electronic)	2214-8019

Keywords

Combinatorial therapy
Immune checkpoint regulation
Precision medicine
Trans-omics
Translational medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-981-15-3266-5_24

Cite this

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KW - Combinatorial therapy

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KW - Precision medicine

KW - Trans-omics

KW - Translational medicine

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Concluding Remarks

Abstract

Publication series

Keywords

UN SDGs

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