Cobalt-catalyzed regioselective syntheses of indeno[2,1-: C] pyridines from nitriles and diynes bearing propargyl fragments

Murong Xu; Zhong Zheng; Mengdan Wang; Lingkai Kong; Yujuan Ao; Yanzhong Li

doi:10.1039/c8ob02419g

Cobalt-catalyzed regioselective syntheses of indeno[2,1-: C] pyridines from nitriles and diynes bearing propargyl fragments

Murong Xu, Zhong Zheng, Mengdan Wang, Lingkai Kong, Yujuan Ao, Yanzhong Li

School of Chemistry and Molecular Engineering

East China Normal University

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

A highly efficient CoI ₂ /o-phenanthroline catalyzed cycloaddition reaction of diynes bearing TBS protected propargylic alcohol fragments with nitriles has been developed. This methodology offers regioselective access, with good functional group tolerance, to various indeno[2,1-c]pyridine derivatives in moderate to excellent yields. It was found that o-phenanthroline as a bidentate nitrogen ligand showed high efficacy in this cycloaddition reaction.

Original language	English
Pages (from-to)	8761-8768
Number of pages	8
Journal	Organic and Biomolecular Chemistry
Volume	16
Issue number	45
DOIs	https://doi.org/10.1039/c8ob02419g
State	Published - 2018

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title = "Cobalt-catalyzed regioselective syntheses of indeno[2,1-: C] pyridines from nitriles and diynes bearing propargyl fragments",

abstract = " A highly efficient CoI 2 /o-phenanthroline catalyzed cycloaddition reaction of diynes bearing TBS protected propargylic alcohol fragments with nitriles has been developed. This methodology offers regioselective access, with good functional group tolerance, to various indeno[2,1-c]pyridine derivatives in moderate to excellent yields. It was found that o-phenanthroline as a bidentate nitrogen ligand showed high efficacy in this cycloaddition reaction.",

author = "Murong Xu and Zhong Zheng and Mengdan Wang and Lingkai Kong and Yujuan Ao and Yanzhong Li",

note = "Publisher Copyright: {\textcopyright} 2018 The Royal Society of Chemistry.",

year = "2018",

doi = "10.1039/c8ob02419g",

language = "英语",

volume = "16",

pages = "8761--8768",

journal = "Organic and Biomolecular Chemistry",

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publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Cobalt-catalyzed regioselective syntheses of indeno[2,1-

T2 - C] pyridines from nitriles and diynes bearing propargyl fragments

AU - Xu, Murong

AU - Zheng, Zhong

AU - Wang, Mengdan

AU - Kong, Lingkai

AU - Ao, Yujuan

AU - Li, Yanzhong

PY - 2018

Y1 - 2018

N2 - A highly efficient CoI 2 /o-phenanthroline catalyzed cycloaddition reaction of diynes bearing TBS protected propargylic alcohol fragments with nitriles has been developed. This methodology offers regioselective access, with good functional group tolerance, to various indeno[2,1-c]pyridine derivatives in moderate to excellent yields. It was found that o-phenanthroline as a bidentate nitrogen ligand showed high efficacy in this cycloaddition reaction.

AB - A highly efficient CoI 2 /o-phenanthroline catalyzed cycloaddition reaction of diynes bearing TBS protected propargylic alcohol fragments with nitriles has been developed. This methodology offers regioselective access, with good functional group tolerance, to various indeno[2,1-c]pyridine derivatives in moderate to excellent yields. It was found that o-phenanthroline as a bidentate nitrogen ligand showed high efficacy in this cycloaddition reaction.

UR - https://www.scopus.com/pages/publications/85056803230

U2 - 10.1039/c8ob02419g

DO - 10.1039/c8ob02419g

M3 - 文章

C2 - 30402643

AN - SCOPUS:85056803230

SN - 1477-0520

VL - 16

SP - 8761

EP - 8768

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 45

ER -

Cobalt-catalyzed regioselective syntheses of indeno[2,1-: C] pyridines from nitriles and diynes bearing propargyl fragments

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