Cobalt-catalyzed regioselective syntheses of indeno[2,1-: C] pyridines from nitriles and diynes bearing propargyl fragments

Murong Xu; Zhong Zheng; Mengdan Wang; Lingkai Kong; Yujuan Ao; Yanzhong Li

doi:10.1039/c8ob02419g

Cobalt-catalyzed regioselective syntheses of indeno[2,1-: C] pyridines from nitriles and diynes bearing propargyl fragments

Murong Xu
, Zhong Zheng
, Mengdan Wang
, Lingkai Kong
, Yujuan Ao
, Yanzhong Li^*

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

East China Normal University

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

A highly efficient CoI ₂ /o-phenanthroline catalyzed cycloaddition reaction of diynes bearing TBS protected propargylic alcohol fragments with nitriles has been developed. This methodology offers regioselective access, with good functional group tolerance, to various indeno[2,1-c]pyridine derivatives in moderate to excellent yields. It was found that o-phenanthroline as a bidentate nitrogen ligand showed high efficacy in this cycloaddition reaction.

Original language	English
Pages (from-to)	8761-8768
Number of pages	8
Journal	Organic and Biomolecular Chemistry
Volume	16
Issue number	45
DOIs	https://doi.org/10.1039/c8ob02419g
State	Published - 2018

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title = "Cobalt-catalyzed regioselective syntheses of indeno[2,1-: C] pyridines from nitriles and diynes bearing propargyl fragments",

abstract = " A highly efficient CoI 2 /o-phenanthroline catalyzed cycloaddition reaction of diynes bearing TBS protected propargylic alcohol fragments with nitriles has been developed. This methodology offers regioselective access, with good functional group tolerance, to various indeno[2,1-c]pyridine derivatives in moderate to excellent yields. It was found that o-phenanthroline as a bidentate nitrogen ligand showed high efficacy in this cycloaddition reaction.",

author = "Murong Xu and Zhong Zheng and Mengdan Wang and Lingkai Kong and Yujuan Ao and Yanzhong Li",

note = "Publisher Copyright: {\textcopyright} 2018 The Royal Society of Chemistry.",

year = "2018",

doi = "10.1039/c8ob02419g",

language = "英语",

volume = "16",

pages = "8761--8768",

journal = "Organic and Biomolecular Chemistry",

issn = "1477-0520",

publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Cobalt-catalyzed regioselective syntheses of indeno[2,1-

T2 - C] pyridines from nitriles and diynes bearing propargyl fragments

AU - Xu, Murong

AU - Zheng, Zhong

AU - Wang, Mengdan

AU - Kong, Lingkai

AU - Ao, Yujuan

AU - Li, Yanzhong

PY - 2018

Y1 - 2018

N2 - A highly efficient CoI 2 /o-phenanthroline catalyzed cycloaddition reaction of diynes bearing TBS protected propargylic alcohol fragments with nitriles has been developed. This methodology offers regioselective access, with good functional group tolerance, to various indeno[2,1-c]pyridine derivatives in moderate to excellent yields. It was found that o-phenanthroline as a bidentate nitrogen ligand showed high efficacy in this cycloaddition reaction.

AB - A highly efficient CoI 2 /o-phenanthroline catalyzed cycloaddition reaction of diynes bearing TBS protected propargylic alcohol fragments with nitriles has been developed. This methodology offers regioselective access, with good functional group tolerance, to various indeno[2,1-c]pyridine derivatives in moderate to excellent yields. It was found that o-phenanthroline as a bidentate nitrogen ligand showed high efficacy in this cycloaddition reaction.

UR - https://www.scopus.com/pages/publications/85056803230

U2 - 10.1039/c8ob02419g

DO - 10.1039/c8ob02419g

M3 - 文章

C2 - 30402643

AN - SCOPUS:85056803230

SN - 1477-0520

VL - 16

SP - 8761

EP - 8768

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 45

ER -

Cobalt-catalyzed regioselective syntheses of indeno[2,1-: C] pyridines from nitriles and diynes bearing propargyl fragments

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